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. 2023 Mar 24;13:1096341. doi: 10.3389/fonc.2023.1096341

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Copyright © 2023 Xia, Li, Sun, Liu, Xu, An, Xu, Zhang, Zhong, Zeng, Ma, He, Zhang, Guan, Li and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene-drug network and molecular docking. (A) The potential gene-drug networks target TIGIT. (B) The 3D structure of the TIGIT protein. (C) The 2D structure of Selumetinib. (D) The 3D structure of Selumetinib. (E) The molecular docking between Selumetinib and TIGIT showed Selumetinib could enter into the active pocket of TIGIT protein. (F) The 2D structure of PD0325901. (G) The 3D structure of PD0325901. (H) The molecular docking between PD0325901and TIGIT showed PD0325901could enter into the active pocket of TIGIT protein.