Table 1.
Detailed clinicopathological characteristics of the KIRC patients.
| Overall | High TIGIT | Low TIGIT | P-value | |
|---|---|---|---|---|
| Number | 530 | 265 | 265 | |
| Age (mean (SD)) | 60.56 (12.14) | 60.42 (11.81) | 60.71 (12.47) | 0.789 |
| Gender = FEMALE/MALE (%) | 186/344 (35.1/64.9) | 81/184 (30.6/69.4) | 105/160 (39.6/60.4) | 0.036 |
| Grade (%) | <0.001 | |||
| G1 | 14 (2.6) | 4 (1.5) | 10 (3.8) | |
| G2 | 227 (42.8) | 91 (34.3) | 136 (51.3) | |
| G3 | 206 (38.9) | 117 (44.2) | 89 (33.6) | |
| G4 | 75 (14.2) | 52 (19.6) | 23 (8.7) | |
| GX | 5 (0.9) | 0 (0.0) | 5 (1.9) | |
| unknow | 3 (0.6) | 1 (0.4) | 2 (0.8) | |
| Stage (%) | <0.001 | |||
| Stage I | 265 (50.0) | 106 (40.0) | 159 (60.0) | |
| Stage II | 57 (10.8) | 34 (12.8) | 23 (8.7) | |
| Stage III | 123 (23.2) | 73 (27.5) | 50 (18.9) | |
| Stage IV | 82 (15.5) | 50 (18.9) | 32 (12.1) | |
| unknow | 3 (0.6) | 2 (0.8) | 1 (0.4) | |
| T (%) | <0.001 | |||
| T1 | 21 (4.0) | 6 (2.3) | 15 (5.7) | |
| T1a | 140 (26.4) | 45 (17.0) | 95 (35.8) | |
| T1b | 110 (20.8) | 60 (22.6) | 50 (18.9) | |
| T2 | 55 (10.4) | 29 (10.9) | 26 (9.8) | |
| T2a | 10 (1.9) | 7 (2.6) | 3 (1.1) | |
| 4 (0.8) | 4 (1.5) | 0 (0.0) | ||
| T3 | 5 (0.9) | 4 (1.5) | 1 (0.4) | |
| T3a | 120 (22.6) | 68 (25.7) | 52 (19.6) | |
| T3b | 52 (9.8) | 35 (13.2) | 17 (6.4) | |
| T3c | 2 (0.4) | 0 (0.0) | 2 (0.8) | |
| T4 | 11 (2.1) | 7 (2.6) | 4 (1.5) | |
| M (%) | 0.002 | |||
| M0 | 420 (79.2) | 206 (77.7) | 214 (80.8) | |
| M1 | 78 (14.7) | 50 (18.9) | 28 (10.6) | |
| MX | 30 (5.7) | 8 (3.0) | 22 (8.3) | |
| unknow | 2 (0.4) | 1 (0.4) | 1 (0.4) | |
| N (%) | 0.107 | |||
| N0 | 239 (45.1) | 121 (45.7) | 118 (44.5) | |
| N1 | 16 (3.0) | 12 (4.5) | 4 (1.5) | |
| NX | 275 (51.9) | 132 (49.8) | 143 (54.0) |