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. 2023 Apr 6;13:5670. doi: 10.1038/s41598-023-32715-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of culturing conditions on the protein expression profile of macrophages. Alveolar macrophages were cultured on uncoated, globular collagen-coated or fibrous collagen-coated tissue culture plastic (n = 6). (a) Partial least squares-discriminant analysis plot of alveolar macrophages in the different conditions showing that the 3 conditions cluster separately. (b) Heatmap of 77 proteins that were differentially expressed (p < 0.025) between uncoated and collagen type I-coated conditions (fibrous and globular pooled). (c) Heatmap of 142 proteins that were differentially expressed (p < 0.05) between macrophages cultured on fibrous or globular collagen. Expressed as Log2 of the median values and statistically tested with an unpaired (b) or a paired (c) Wilcoxon test.