Table 2.

Effect of collagen morphology on the protein expression profile of macrophages.

Gene name	Protein name	Fold change F/G	p-value
Serpinf1	Pigment epithelium-derived factor	12.66	3.13E−02
Dctn4	Dynactin subunit 4	9.97	3.13E−02
Rbm42	RNA-binding protein 42	9.86	3.13E−02
Mrps15	28S ribosomal protein S15, mitochondrial	9.52	3.13E−02
Atp7a	Copper-transporting ATPase 1	6.11	3.13E−02
Ppic	Peptidyl-prolyl cis–trans isomerase C	4.97	3.13E−02
Prim2	DNA primase large subunit	3.83	3.13E−02
Trim23	E3 ubiquitin-protein ligase TRIM23	3.64	3.13E−02
Mmp8	Neutrophil collagenase	3.63	3.13E−02
Uba5	Ubiquitin-like modifier-activating enzyme 5	3.40	3.13E−02
Plekha2	Pleckstrin homology domain-containing family A member 2	3.12	3.13E−02
Tmsb4x	Thymosin beta-4	3.09	3.13E−02
Unc45a	Protein unc-45 homolog A	2.61	3.13E−02
Ercc4	DNA repair endonuclease XPF	2.51	3.13E−02
Retreg3	Reticulophagy regulator 3	2.41	3.13E−02
Cybc1	Cytochrome b-245 chaperone 1	2.25	3.13E−02
Yipf4	Protein YIPF4	2.24	3.13E−02
Gdi1	Rab GDP dissociation inhibitor alpha	2.12	3.13E−02
Rdh11	Retinol dehydrogenase 11	2.11	3.13E−02
Rab11b	Ras-related protein Rab-11B	2.10	3.13E−02
Rtn3	Reticulon-3	2.05	3.13E−02
Wtap	Pre-mRNA-splicing regulator WTAP	2.05	3.13E−02
Apoo	MICOS complex subunit Mic26 (Apolipoprotein O)	2.02	3.13E−02
Pdxk	Pyridoxal kinase	0.50	3.13E−02
Txnrd1	Thioredoxin reductase 1, cytoplasmic	0.44	3.13E−02
Ncbp1	Nuclear cap-binding protein subunit 1	0.41	3.13E−02
Tram1	Translocating chain-associated membrane protein 1	0.39	3.13E−02

23 proteins were expressed at levels more than twofold higher in macrophages cultured on fibrous collagen type I-coated tissue culture plastic compared to macrophages in globular collagen-coated conditions, while four proteins were expressed at levels more than twofold lower (fold change < 0.5). N = 6, p < 0.05 was considered significant.