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. 2023 Mar 24;14:1104560. doi: 10.3389/fimmu.2023.1104560

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Copyright © 2023 Liu, Wan, Bai and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of differences between two subtypes in immune microenvironment status and immune signature expression levels. (A) The differential estimated proportion of 22 CIBERSORT immune cell types in DAMPs-associated subtypes. The central line represents the median value. The bottom and top of the boxes are the 25th and 75th percentiles (interquartile range). (B) Stromal score in DAMPs-associated subtypes. (C) Immune score in DAMPs-associated subtypes. (D) ESTIMATE score difference between the two subtypes in the training cohort. (E) Expression differences in CD8A, PD-1, PD-L1 and CTLA4 between two subtypes. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.