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. 2023 Mar 24;14:1127982. doi: 10.3389/fimmu.2023.1127982

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Copyright © 2023 Li, Yu, Chen, Hou, Wang, Qian and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression validation and functional exploration of two key DRGs. (A) GEPIA database analyses demonstrated the differential expression of GNPNAT1 and MORF4L2 in BRCA and normal breast tissues. (B, C) RT-qPCR and IHC (10×) experiments showed the elevated expression of GNPNAT1 and MORF4L2 in BRCA tissues compared with adjacent normal tissues. (D) IHC assays (10×) revealed the association of key DRGs with macrophages and CD8⁺ T cells. (E) The expression of GNPNAT1 and MORF4L2 was knocked down in the targeted group. (F, G) Knockdown of either GNPNAT1 or MORF4L2 could suppress the proliferation activity of MCF-7 cells. (*P < 0.05, ****P < 0.0001).