Table 1.
Patient characteristics, cardiovascular risk factors and childhood GH status of four patients with PWS with cardiovascular events, compared to 117 PWS adults without cardiovascular events.
| Age (years) a | Genotype | BMI (kg/m2) | Type 2 diabetes mellitus | Hyper-tension | Hyperchol-esterolemia | Sleep apnea | GH during childhood | |
|---|---|---|---|---|---|---|---|---|
| Patient 1 | 39 | Deletion | 45 | Yes | Yes | Yes | Yes | No |
| Patient 2 | 37 | Deletion | 44 | Yes | No | Yes | Yes | No |
| Patient 3 | 29 | Deletion | 48 | No | No | No | No | No |
| Patient 4 | 32 | Unknown | 53 | NA | Yes | No | NA | No |
| Control (n=117) | 28 [20 – 38] | Deletion: 61 (52%) mUPD: 42 (36%) ICD: 3 (3%) Unknown: 11 (9%) |
29 [26 – 35] | 13 (11%) | 17 (15%) | 20 (17%) | 17 (15%) | 58 (50%) |
Data presented as yes (present), no (absent) or NA (not available) for individual patients and as n (%) for control PWS adults. For controls the age and BMI are given as median [IQR].
Abbreviations: body mass index (BMI), growth hormone (GH), imprinting center defect (ICD), maternal parental disomy (mUPD). a Age at first event for cases and age at data collection for controls.