Table 2.

Physical complaints and signs of cardiac decompensation of four patients with PWS with cardiovascular events, compared to 117 PWS adults without cardiovascular events.

	Chest pain	Peripheral edema	Orthopnea	Progression of edema	Increased NT-proBNP	Difficulty interpreting cardiac ultrasound	Signs of pulmonary hypertension a
Patient 1	No	Yes	Yes	Yes	No	Yes	No
Patient 2	Yes	Yes	NA	Yes	NA	Yes	Yes
Patient 3	No	Yes	Yes	Yes	Yes	Yes	Yes
Patient 4	No	Yes	Yes	Yes	Yes	NA	Yes
Controlb	2/91 (2%)	29/95 (31%)	1/90 (1%)	NA	NA	NA	NA

Data presented as yes (present), no (absent), NA (not available) for individual patients and as number of controls with the outcome / total number of controls for whom the outcome was known (%) for the group of control patients.

^a Signs of pulmonary hypertension include: right axis deviation on electrocardiogram, signs of increased systolic right ventricle pressure on echocardiogram (in absence of pulmonary valve stenosis): increased tricuspid regurgitation velocity, enlarged vena cava and/or right ventricle dilatation or hypertrophy. ^b Number of controls differs as a result of missing values.