Table 2.
Values of laboratory parameters and biomarkers (first available measures performed within 48 h from ICU admission).
| Predictive values | Overall (N = 209) | Survivors (N = 82) | Non-survivors (N = 127) | P-value |
|---|---|---|---|---|
| MR-proADM, nmol/L, mean ± std [N = 198] | 1.85 (±2.16) | 1.17 (±0.73) | 2.31 (±2.63) | <0.0001 |
| D-dimer, ng/mL [N = 205] | 9,235.7 (±19,150) | 7,143.7 (±17,342.1) | 10,574.6 (±20,176.2) | 0.0019 |
| LDH, UI/L [N = 205] | 942.2 (±544.4) | 780.3 (±281.3) | 1,048.1 (±641.5) | <0.0001 |
| NT-proBNP, ng/L [N = 197] | 2,049.1 (±7,056.1) | 669.5 (±1,215.7) | 2,915.6 (±8,856.3) | <0.0001 |
| C-RP, mg/L [N = 208] | 115.2 (±98.1) | 109.3 (±99.4) | 118.9 (±97.5) | 0.3562 |
| PCT, μg/L [N = 207] | 2.30 (±6.81) | 0.86 (±2.16) | 3.20 (±8.44) | 0.0251 |
| Myoglobin, μg/L [N = 193] | 186.3 (±307.1) | 156.9 (±290) | 205 (±317.3) | 0.0356 |
| CK, UI/L [N = 206] | 254.5 (±592.6) | 182.8 (±235.9) | 301 (±734.3) | 0.7823 |
| Copeptin, pmol/L [N = 154] | 34.0 (±50) | 30.3 (±40.6) | 36.3 (±55.3) | 0.7712 |
| Ferritin ng/ml, mean ± std [N = 182] | 1,931.3 (±2,367.9) | 1,610.3 (±1,414.7) | 2,141.4 (±2,809.7) | 0.1620 |
| Troponin-I hs, ng/L [N = 193] | 43.3 (±112.9) | 24.4 (±57.3) | 55.1 (135.5) | <0.0001 |
| Neutrophils, cell x 10*9/L [N = 206] | 11 (±7.9) | 9.65 (±9.1) | 11.9 (±6.9) | 0.0012 |
| Lymphocytes, cell x 10*9/L [N = 206] | 0.95 (±2.75) | 0.87 (±1.0) | 0.99 (±3.45) | 0.0157 |
| Lymphocytes B (CD19+) [N = 157] | 155.8 (±201.2) | 160.7 (±241.7) | 152.6 (±171) | 0.3044 |
| Lymphocytes T (CD3+) [N = 157] | 388.4 (±256.7) | 407.1 (±227.8) | 376.2 (±274.4) | 0.1179 |
| Lymphocytes T helper (CD3+CD4+) [N = 157] | 271.9 (±200.5) | 282 (±181) | 265.4 (±212.9) | 0.1781 |
| Lymphocytes T suppressor (CD3+CD8+) [N = 157] | 107.6 (±73.9) | 111.4 (±69.4) | 105.2 (±76.9) | 0.2985 |
| Lymphocytes natural killer (CD16+CD56+) [N = 157] | 61.9 (±60) | 76.5 (±71.5) | 52.3 (±49.3) | 0.0078 |
| Immunoglobulin A, g/L [N = 164] | 262.6 (±139.3) | 254 (±111.7) | 267.5 (±153.3) | 0.7808 |
| Immunoglobulin G, g/L [N = 163] | 922 (±475.4) | 873.4 (±200.1) | 949.5 (±575.2) | 0.8332 |
| Immunoglobulin M, g/L [N = 163] | 113.8 (±126) | 110.5 (±85.5) | 115.6 (±144.4) | 0.8103 |
| Interleukin 6, pg/mL [N = 109] | 463.9 (±1,074.1) | 343.6 (±1,635.7) | 528.3 (±1,747.7) | 0.0093 |
MR-proADM, mid-regional pro-adrenomedullin; LDH, lactate dehydrogenase; NT-proBNP, N-terminal prohormone of brain natriuretic peptide; CRP, C-reactive protein; PCT, procalcitonin; CK, creatine kinase. The bold values indicate statistical significance.