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. 2023 Mar 24;14:1127708. doi: 10.3389/fneur.2023.1127708

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Copyright © 2023 Neumann, Seshadri, Thompson, Broshek, Druzgal, Massey, Newman, Reyes, Simpson, McCauley, Patrie, Stone, Kundu and Resch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Volumetric VT maps quantify persistent microglial activation in athletes diagnosed with SC (Group 1) who have achieved uRTP compared to controls (Group 2). (A) Caudate. (B) Thalamus. (C) Putamen. (D) Hippocampus. (E) Amygdala. Regional VT maps are computed (top) from a voxel-based parametric PET map. Geometric means (bottom-green line) of voxels within each CNS region are compared (bottom) between SC athletes and age- and genotype-matched healthy controls. Across 164 regions, the regions associated with consistent and significantly elevated microglial activation are the bilateral caudate, thalamus, putamen, hippocampus, and amygdala.