Table 2A.

Reactome pathway analysis for enriched pathways (p<0.05) comprised of at least two genes with significant differences in methylation by sex for each medulloblastoma subgroup*.

Reactome Pathway Name	pValue	Submitted entities found
SHH
YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.00005	TEAD4;RUNX2
Loss of Function of TGFBR1 in Cancer	0.00283	SMAD2;FKBP1B
Signaling by TGF-beta Receptor Complex in Cancer	0.00462	SMAD2;FKBP1B
SOS-mediated signalling	0.00566	GRB2;IRS2
Signal attenuation	0.00936	GRB2;IRS2
RET signaling	0.01247	GRB2;IRS2;SHANK3
Advanced glycosylation endproduct receptor signaling	0.01387	PRKCSH;CAPZA1
Regulation of RUNX2 expression and activity	0.01409	RUNX2;RBX1
Regulation of KIT signaling	0.01731	GRB2;SOCS6
Pre-NOTCH Transcription and Translation	0.01772	NOTCH3;H3F3A
Erythropoietin activates RAS	0.01915	GRB2;IRS2
WNT5A-dependent internalization of FZD4	0.02107	ARRB2;AP2B1
Signaling by NTRK1 (TRKA)	0.02211	ADCYAP1;NAB1;GRB2;IRS2;AP2B1
Signaling by NOTCH	0.02602	NOTCH3;TLE1;H3F3A;ARRB2;RBX1
Intrinsic Pathway for Apoptosis	0.03480	YWHAQ;APAF1
Signaling by NTRKs	0.03823	ADCYAP1;NAB1;GRB2;IRS2;AP2B1
Pre-NOTCH Expression and Processing	0.03872	NOTCH3;H3F3A
mTORC1-mediated signalling	0.03900	FKBP1B;EIF4EBP1
RAB geranylgeranylation	0.04045	RAB23;RAB12;RAB33B
Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.04083	H3F3A;HOXC4
Activation of HOX genes during differentiation	0.04083	H3F3A;HOXC4
SARS-CoV-1-host interactions	0.04300	YWHAQ;NAB1;FKBP1B
Group 4
Activation of HOX genes during differentiation	0.00020	HOXC4;POLR2L
Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.00020	HOXC4;POLR2L
Organelle biogenesis and maintenance	0.00149	ATP5J;CSNK1D;RAB11FIP3;GABPA
Mitochondrial biogenesis	0.00405	ATP5J;GABPA

*No pathways were detected for WNT or Group 3.