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. 2022 Dec 1;8(3-4):63–79. doi: 10.1159/000527224

Table 2.

Heritability and co-heritability of measured IQ and the prediction of IQ by each modeling procedure

Edge/model Network Heritability SE rG with IQ SE rE with IQ SE rG CI corrected
Angular gyrus to PCC Default to ventral attention 0.104 0.031 −0.226 0.130 −0.037 0.028 ±0.361
Right frontal parietal network regions and contralateral cerebellum to PCC Frontoparietal to ventral attention 0.070 0.030 −0.353 0.167 −0.008 0.027 ±0.464
Medial superior occipital to left middle frontal and temporal structures Dorsal attention to default mode 0.087 0.030 −0.130 0.141 −0.064 0.028 ±0.390
Precuneus, lateral occipital and fusiform to middle temporal gyrus Visual to default mode 0.102 0.030 −0.252 0.133 0.004 0.028 ±0.368
Frontal pole to left frontoparietal network and cerebellum to FP Frontoparietal to ventral attention 0.118 0.030 0.105 0.122 −0.049 0.028 ±0.339
Precuneus and PCC to PCC Default mode to default mode 0.038 0.029 −0.310 0.241 0.009 0.027 ±0.669
CBPM* 0.181 0.031 0.422 0.092 0.123 0.029 ±0.256
LASSO* 0.143 0.031 0.518 0.105 0.107 0.028 ±0.290
Ridge* 0.155 0.031 0.576 0.100 0.116 0.028 ±0.278

The heritability of each edge that was significantly associated after Bonferroni correction and the prediction of IQ and co-heritability between each edge and each predicted model of IQ with measured IQ. rG, genetic correlation between the IQ predictor and measured IQ; positive genetic correlation means that the genes that influence stronger connectivity (correlated or anti-correlated) are related to better IQ, and negative means genes that influence connectivity are related to lower IQ. rE, environmental correlation, which is the proportion of the phenotypic correlation that remains after accounting for the genetic correlation. Standard errors (SE) follow their respective statistic. We Bonferroni corrected the confidence interval to the 99.99% interval to account for multiple testing. PCC, posterior cingulate cortex.

*

p < 0.05 rG with brain-based predicted IQ post Bonferroni correction.