Table 2.
Edge/model | Network | Heritability | SE | rG with IQ | SE | rE with IQ | SE | rG CI corrected |
---|---|---|---|---|---|---|---|---|
Angular gyrus to PCC | Default to ventral attention | 0.104 | 0.031 | −0.226 | 0.130 | −0.037 | 0.028 | ±0.361 |
Right frontal parietal network regions and contralateral cerebellum to PCC | Frontoparietal to ventral attention | 0.070 | 0.030 | −0.353 | 0.167 | −0.008 | 0.027 | ±0.464 |
Medial superior occipital to left middle frontal and temporal structures | Dorsal attention to default mode | 0.087 | 0.030 | −0.130 | 0.141 | −0.064 | 0.028 | ±0.390 |
Precuneus, lateral occipital and fusiform to middle temporal gyrus | Visual to default mode | 0.102 | 0.030 | −0.252 | 0.133 | 0.004 | 0.028 | ±0.368 |
Frontal pole to left frontoparietal network and cerebellum to FP | Frontoparietal to ventral attention | 0.118 | 0.030 | 0.105 | 0.122 | −0.049 | 0.028 | ±0.339 |
Precuneus and PCC to PCC | Default mode to default mode | 0.038 | 0.029 | −0.310 | 0.241 | 0.009 | 0.027 | ±0.669 |
CBPM* | 0.181 | 0.031 | 0.422 | 0.092 | 0.123 | 0.029 | ±0.256 | |
LASSO* | 0.143 | 0.031 | 0.518 | 0.105 | 0.107 | 0.028 | ±0.290 | |
Ridge* | 0.155 | 0.031 | 0.576 | 0.100 | 0.116 | 0.028 | ±0.278 |
The heritability of each edge that was significantly associated after Bonferroni correction and the prediction of IQ and co-heritability between each edge and each predicted model of IQ with measured IQ. rG, genetic correlation between the IQ predictor and measured IQ; positive genetic correlation means that the genes that influence stronger connectivity (correlated or anti-correlated) are related to better IQ, and negative means genes that influence connectivity are related to lower IQ. rE, environmental correlation, which is the proportion of the phenotypic correlation that remains after accounting for the genetic correlation. Standard errors (SE) follow their respective statistic. We Bonferroni corrected the confidence interval to the 99.99% interval to account for multiple testing. PCC, posterior cingulate cortex.
p < 0.05 rG with brain-based predicted IQ post Bonferroni correction.