Table 2. Trends in the incidence of early-onset colorectal cancer (20–49 years) by sex and diagnosis in different segments of the colon in Germany (Bremen, Hamburg, Münster, Rhineland–Palatinate, Saarland, and Schleswig–Holstein) from 1999 to 2018.

Site /subsite (ICD-10)	Males			Females			Total
	AAPC	95% CI	Trend	AAPC	95% CI	Trend	AAPC	95% CI	Trend
Colon (C18)	1.62	[0.69; 2.56]	Increasing	1.39	[0.55; 2.24]	Increasing	1.51	[0.76; 2.27]	Increasing
Proximal colon (C18.0–C18.4)	3.26	[2.00; 4.53]	Increasing	2.99	[2.17; 3.83]	Increasing	3.10	[2.24; 3.97]	Increasing
Distal colon (C18.5–C18.7)	0.95	[−0.23; 2.15]	Stable	0.55	[−0.62; 1.73]	Stable	0.76	[−0.27; 1.81]	Stable
Colon overlapping / NOS (C18.8–C18.9)	−2.28	[−4.18; −0.34]	Decreasing	−2.97	[−5.73; −0.12]	Decreasing	−2.39	[−4.05; −0.68]	Decreasing
Rectum (C19–C20)	0.57	[−0.18; 1.33]	Stable	1.29	[0.38; 2.20]	Increasing	0.87	[0.28; 1.46]	Increasing

AAPC, Average annual percentage change; NOS, not otherwise specified; 95% CI, 95% confidence intervalICD-10, Tenth Revision of the International Statistical Classification of Diseases and Related Health Problems