Table 3. Trends in the incidence of early-onset colorectal cancer (20–49 years) by sex and tumor size/tumor extension in Germany (Bremen, Hamburg, Münster, Rhineland–Palatinate, Saarland, and Schleswig–Holstein) from 1999 to 2018.

T categoryof the TNM classification	Males			Females			Total
	AAPC	95% CI	Trend	AAPC	95% CI	Trend	AAPC	95% CI	Trend
T1 and T2	2.96	[1.54; 4.39]	Increasing	4.84	[3.35; 6.34]	Increasing	3.85	[2.75; 4.96]	Increasing
T3+	1.07	[0.32; 1.82]	Increasing	0.22	[−0.40; 0.84]	Stable	0.67	[0.17; 1.18]	Increasing
Unknown	0.07	[−1.32; 1.47]	Stable	0.67	[−0.68; 2.04]	Stable	0.36	[−0.80; 1.54]	Stable

AAPC= Average annual percentage change; TNM, tumor (T), nodes (N), and metastases (M); 95% CI, 95% confidence interval