eTable 3. Exploratory analyses of the trends in the incidence of early-onset colon cancer (20–49 years), excluding appendiceal cancer, by sex and diagnosis in different subsites of the colon in Germany (Bremen, Hamburg, Münster, Rhineland–Palatinate, Saarland, and Schleswig–Holstein) from 1999 to 2018.

Site/colonic subsite (ICD-10)	Males			Females			Total
	AAPC	95% CI	Trend	AAPC	95% CI	Trend	AAPC	95% CI	Trend
Colorectal cancer excl. appendix (C18; C18.2–C20)	0.77	[0.09; 1.44]	Increasing	0.53	[0.04; 1.01]	Increasing	0.65	[0.18; 1.13]	Increasing
Colon excl. appendix (C18.0; C18.2–C18.9)	0.92	[−0.11; 1.96]	Stable	−0.01	[−0.75; 0.74]	Stable	0.49	[−0.26; 1.26]	Stable
Proximal colon excl. appendix (C18.0; C18.2–C18.4)	1.94	[0.60; 3.30]	Increasing	0.11	[−0.78; 1.02]	Stable	1.10	[0.26; 1.95]	Increasing
Appendix (C18.1)	9.28	[5.76; 12.92]	Increasing	9.52	[6.30; 12.85]	Increasing	9.17	[6.46; 11.96]	Increasing

AAPC, Average annual percentage change; 95% CI, 95% confidence interval;

ICD-10, Tenth Revision of the International Statistical Classification of Diseases and Related Health Problems