Table 2.
Geriatric Assessment Findings at Baseline by Cohort
| Baseline Geriatric Assessment Domains | Cohort 1 (triple-negative; n=20) (n, %) | Cohort 2 (hormone receptor- positive; n=20) (n, %) | |||
|---|---|---|---|---|---|
| Description | Mean (SD) | Median (range) | Mean (SD) | Median (range) | |
| Functional status | |||||
| ADLs (Medical Outcomes study [MOS]) subscale50 | Measures limitations in physical function | 68.8(29) | 75.0(5.0–100) | 77.7(21.8) | 85.0(35–100) |
| Instrumental Activities of Daily Living (IADLs) using Older American Resources and Services (OARS) subscale51 | Measures ability to complete activities to maintain independence | 12.8(1.7) | 14.0(9.0–14.0) | 13.8(0.4) | 14.0(13–14) |
| Falls | Number with at least 1 fall in last 6 months (%) | -- | 3(15%) | -- | 3(15%) |
| Karnofsky performance status (by study staff)52 | Global scale for patient function (0–100) | 92.9(6.9) | 90(80–100) | 93.9(8.5) | 100(70–100) |
| Timed up and go53 (seconds) (by study staff) | Time it takes for individual to stand up, walk 10 feet, return to chair, and sit back down (>12 seconds is at risk for falls) | 11.8(4.1) | 11.0(4–22) | 11.4(3.6) | 11.0(6–19.8) |
| Comorbidity OARS physical health scale51 | Assesses the presence of 13 comorbid conditions and effect of illness on daily activities | 3.2(1.7) | 3.0(0–6) | 15(1.3) | 1.0(0–4) |
| Psychological state Mental health inventory54 | Evaluates level of depression and anxiety in the last month | 80.1(16.4) | 82.4(40.0-100) | 78.6(12.5) | 82.2(56.9–97.3) |
| Social activity 54,55 | 62.3(17.2) | 66.7(25.0-83.3) | 57.7(20.3) | 58.3(16.7–83.3) | |
| MOS social support (Overall) | Overall score | 90.4(12.0) | 97.9(68.8-100) | 87.3(15.3) | 91.7(52.1–100) |
| MOS social support (tangible subscale) | Evaluates the self-reported availability of tangible/physical support | 87.9(16.0) | 93.8(56.3-100) | 88.9(16.6) | 100(43.8–100) |
| MOS social support (emotional/informational subscale) | Evaluates the self-reported availability of emotional/informational support | 91.7(12) | 100(68.8–100) | 86.5(18.1) | 90.6(37.5–100) |
| Nutrition | |||||
| Body mass index | Weight (kg) / height (m2) | 28.5(5.3) | 27.9(20.4–41.7) | 30.9(6.1) | 30.5(23.4–47.1) |
| Weight loss | % with ≥5% unintentional weight loss in last 6 months | 2(10%) | 1(5%) | 2(10%) | 1(5%) |
| Cognition (Blessed Orientation Memory Concentration56 (% with <11) | Cognitive assessment, score ≥11 represents impairment | 16(80%) | 3(15%) | 19(95%) | 1(5%) |
ADLs, Activities of Daily Living; IADLs, Instrumental Activities of Daily Living; OARS, Older American Resources and Services