Table 3. AUC, best cut-off, sensitivity, specificity, PPV, NPV, and accuracy at predicting overall PCa.
| Variables | AUC | Cut-off | Sensitivity (%), 95% CI | Specificity (%), 95% CI | PPV (%), 95% CI | NPV (%), 95% CI | Accuracy (%) |
|---|---|---|---|---|---|---|---|
| Age | 0.678 | ≥68.5 | 69.4 (59.8–77.6) | 58.5 (50.6–66.1) | 53.1 (44.7–61.4) | 73.8 (65.3–81.0) | 62.9 |
| PSA | 0.680 | ≥6.425 | 73.0 (63.6–80.8) | 55.5 (47.5–63.2) | 52.6 (44.4–60.6) | 75.2 (66.4–82.4) | 62.5 |
| TPV | 0.671 | <34.5 | 49.5 (40.0–59.1) | 78.7 (71.4–84.5) | 61.1 (50.2–71.0) | 69.7 (62.5–76.1) | 66.9 |
| PZV | 0.639 | <19.9 | 55.9 (46.1–65.2) | 64.6 (56.7–71.8) | 51.7 (42.4–60.8) | 68.4 (60.4–75.5) | 61.2 |
| PZ-PSAD | 0.731 | ≥0.368 | 64.9 (55.2–73.5) | 73.2 (65.6–79.6) | 62.1 (52.6–70.8) | 75.5 (67.9–81.8) | 69.8 |
| TZ-PSAD | 0.736 | ≥0.353 | 71.2 (61.7–79.2) | 68.9 (61.1–75.8) | 60.8 (51.8–69.1) | 77.9 (70.1–84.2) | 69.8 |
| PSAD | 0.764 | ≥0.218 | 59.5 (49.7–68.5) | 84.8 (78.1–89.7) | 72.5 (62.0–81.1) | 75.5 (68.6–81.4) | 74.5 |
AUC, area under the receiver operating characteristic curve; PPV, positive predictive value; CI, confidence interval; NPV, negative predictive value; PSA, prostate-specific antigen; TPV, total prostate volume; PZV, peripheral zone volume; PZ-PSAD, peripheral zone prostate-specific antigen density; TZ-PSAD, transition zone prostate-specific antigen density.