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hCLN3 protein is expressed in the brains of scAAV9.Mecp2.CLN3 treated Cln3 Δex7/8 mice. AAV9 administration generates hCLN3 protein expression in the thalamus (VPM/VPL, (A), somatosensory cortex (S1BF; (B), and CA3 of the hippocampus (C), most notably at 6 months of age. Two-way ANOVA, Tukey correction. Mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Scale Bar = 200 µm, images presented are from 6 months of age. 12 images/region/animal were examined.
