Table 1. Baseline Characteristics of NSCLC patients with brain metastasis.
| Characteristic | Variable | Overall (n=4,920) | No early death (n=2,788) | All-cause early death (n=2,132) | Cancer-specific early death (n=2,021) |
|---|---|---|---|---|---|
| Age, years | ≤65 | 2,632 (53.5) | 1,687 (60.5) | 945 (44.3) | 902 (44.6) |
| 66–71 | 1,011 (20.5) | 530 (19.0) | 481 (22.6) | 446 (22.1) | |
| >71 | 1,277 (26.0) | 571 (20.5) | 706 (33.1) | 673 (33.3) | |
| Sex | Male | 2,677 (54.4) | 1,413 (50.7) | 1,264 (59.3) | 1,187 (58.7) |
| Female | 2,243 (45.6) | 1,375 (49.3) | 868 (40.7) | 834 (41.3) | |
| Race | White | 3,832 (77.9) | 2,129 (76.4) | 1,703 (79.9) | 1,617 (80.0) |
| Black | 577 (11.7) | 324 (11.6) | 253 (11.9) | 237 (11.7) | |
| Other | 511 (10.4) | 335 (12.0) | 176 (8.3) | 167 (8.3) | |
| Marital | Married | 2,682 (54.5) | 1,600 (57.4) | 1,082 (50.8) | 1,020 (50.5) |
| Unmarried | 2,238 (45.5) | 1,188 (42.6) | 1,050 (49.2) | 1,001 (49.5) | |
| Grade | I | 188 (3.8) | 124 (4.4) | 64 (3.0) | 60 (3.0) |
| II | 1,260 (25.6) | 835 (29.9) | 425 (19.9) | 400 (19.8) | |
| III | 3,325 (67.6) | 1,757 (63.0) | 1,568 (73.5) | 1,487 (73.6) | |
| IV | 147 (3.0) | 72 (2.6) | 75 (3.5) | 74 (3.7) | |
| Tumor size, mm | ≤46 | 2,287 (46.5) | 1,392 (49.9) | 895 (42.0) | 841 (41.6) |
| 47–70 | 1,515 (30.8) | 879 (31.5) | 636 (29.8) | 602 (29.8) | |
| >70 | 1,118 (22.7) | 517 (18.5) | 601 (28.2) | 578 (28.6) | |
| Histology | LUAD | 3,237 (65.8) | 1,998 (71.7) | 1,239 (58.1) | 1,173 (58.0) |
| ADSQC | 83 (1.7) | 48 (1.7) | 35 (1.6) | 33 (1.6) | |
| SQCC | 770 (15.7) | 364 (13.1) | 406 (19.0) | 385 (19.0) | |
| LCLC | 78 (1.6) | 40 (1.4) | 38 (1.8) | 37 (1.8) | |
| Other | 752 (15.3) | 338 (12.1) | 414 (19.4) | 393 (19.4) | |
| T | T1 | 492 (10.0) | 331 (11.9) | 161 (7.6) | 147 (7.3) |
| T2 | 1,520 (30.9) | 946 (33.9) | 574 (26.9) | 545 (27.0) | |
| T3 | 1,343 (27.3) | 708 (25.4) | 635 (29.8) | 604 (29.9) | |
| T4 | 1,565 (31.8) | 803 (28.8) | 762 (35.7) | 725 (35.9) | |
| N | N0 | 1,180 (24.0) | 705 (25.3) | 475 (22.3) | 450 (22.3) |
| N1 | 488 (9.9) | 294 (10.5) | 194 (9.1) | 180 (8.9) | |
| N2 | 2,386 (48.5) | 1,296 (46.5) | 1,090 (51.1) | 1,028 (50.9) | |
| N3 | 866 (17.6) | 493 (17.7) | 373 (17.5) | 363 (18.0) | |
| Surgery | No | 4,627 (94.0) | 2,556 (91.7) | 2,071 (97.1) | 1,970 (97.5) |
| Yes | 293 (6.0) | 232 (8.3) | 61 (2.9) | 51 (2.5) | |
| Radiation | No/Unknown | 1,062 (21.6) | 386 (13.8) | 676 (31.7) | 628 (31.1) |
| Yes | 3,858 (78.4) | 2,402 (86.2) | 1,456 (68.3) | 1,393 (68.9) | |
| Chemotherapy | No/Unknown | 2,151 (43.7) | 607 (21.8) | 1,544 (72.4) | 1,459 (72.2) |
| Yes | 2,769 (56.3) | 2,181 (78.2) | 588 (27.6) | 562 (27.8) | |
| Bone metastasis | No | 3,434 (69.8) | 2,021 (72.5) | 1,413 (66.3) | 1,324 (65.5) |
| Yes | 1,486 (30.2) | 767 (27.5) | 719 (33.7) | 697 (34.5) | |
| Liver metastasis | No | 4,203 (85.4) | 2,475 (88.8) | 1,728 (81.1) | 1,623 (80.3) |
| Yes | 717 (14.6) | 313 (11.2) | 404 (18.9) | 398 (19.7) |
Data are presented as n (%). NSCLC, non-small cell lung cancer; LUAD, lung adenocarcinoma; ADSQC, adenosquamous carcinoma; SQCC, squamous cell carcinoma; LCLC, large-cell lung carcinoma.