Table 3. Univariate logistic regression for the risk factors of early death.
| Variable | Overall early-death | Cancer-specific early-death | |||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | ||
| Age (years) | |||||||
| ≤65 | Ref. | Ref. | |||||
| 66–71 | 1.538 | 1.291–1.833 | <0.001 | 1.427 | 1.196–1.703 | <0.001 | |
| >71 | 2.060 | 1.753–2.423 | <0.001 | 2.015 | 1.714–2.371 | <0.001 | |
| Sex | |||||||
| Male | Ref. | Ref. | |||||
| Female | 0.739 | 0.645–0.846 | <0.001 | 0.781 | 0.681–0.895 | <0.001 | |
| Race | |||||||
| White | Ref. | Ref. | |||||
| Black | 1.009 | 0.819–1.241 | 0.933 | 0.986 | 0.799–1.214 | 0.891 | |
| Other | 0.678 | 0.535–0.855 | 0.001 | 0.673 | 0.529–0.851 | 0.001 | |
| Marital status | |||||||
| Married | Ref. | Ref. | |||||
| Unmarried | 1.323 | 1.155–1.515 | <0.001 | 1.322 | 1.154–1.516 | <0.001 | |
| Grade | |||||||
| I | Ref. | Ref. | |||||
| II | 0.799 | 0.545–1.182 | 0.256 | 0.797 | 0.541–1.186 | 0.255 | |
| III | 1.414 | 0.981–2.058 | 0.066 | 1.439 | 0.994–2.106 | 0.057 | |
| IV | 1.545 | 0.916–2.617 | 0.104 | 1.712 | 1.012–2.912 | 0.046 | |
| Tumor size (mm) | |||||||
| ≤46 | Ref. | Ref. | |||||
| 47–70 | 1.052 | 0.897–1.233 | 0.532 | 1.060 | 0.902–1.244 | 0.479 | |
| >70 | 1.813 | 1.527–2.153 | <0.001 | 1.874 | 1.578–2.227 | <0.001 | |
| Histology | |||||||
| LUAD | Ref. | Ref. | |||||
| ADSQC | 0.989 | 0.577–1.658 | 0.966 | 1.078 | 0.629–1.808 | 0.778 | |
| SQCC | 1.984 | 1.644–2.397 | <0.001 | 1.938 | 1.606–2.341 | <0.001 | |
| LCLC | 1.391 | 0.787–2.441 | 0.250 | 1.518 | 0.858–2.663 | 0.146 | |
| Other | 1.849 | 1.526–2.243 | <0.001 | 1.838 | 1.516–2.229 | <0.001 | |
| T stage | |||||||
| T1 | Ref. | Ref. | |||||
| T2 | 1.130 | 0.876–1.464 | 0.349 | 1.228 | 0.946–1.602 | 0.126 | |
| T3 | 1.740 | 1.347–2.257 | <0.001 | 1.876 | 1.444–2.450 | <0.001 | |
| T4 | 1.795 | 1.397–2.317 | <0.001 | 1.948 | 1.508–2.532 | <0.001 | |
| N stage | |||||||
| N0 | Ref. | Ref. | |||||
| N1 | 0.921 | 0.709–1.193 | 0.534 | 0.923 | 0.708–1.199 | 0.549 | |
| N2 | 1.281 | 1.082–1.518 | 0.004 | 1.270 | 1.071–1.507 | 0.006 | |
| N3 | 1.116 | 0.903–1.379 | 0.309 | 1.167 | 0.943–1.444 | 0.155 | |
| Surgery | |||||||
| No | Ref. | Ref. | |||||
| Yes | 0.342 | 0.239–0.480 | <0.001 | 0.297 | 0.201–0.425 | <0.001 | |
| Radiation | |||||||
| No/Unknown | Ref. | Ref. | |||||
| Yes | 0.344 | 0.290–0.407 | <0.001 | 0.385 | 0.325–0.454 | <0.001 | |
| Chemotherapy | |||||||
| No/Unknown | Ref. | Ref. | |||||
| Yes | 0.116 | 0.099–0.135 | <0.001 | 0.132 | 0.113–0.154 | <0.001 | |
| Bone metastasis | |||||||
| No | Ref. | Ref. | |||||
| Yes | 1.352 | 1.170–1.563 | <0.001 | 1.424 | 1.231–1.648 | <0.001 | |
| Liver metastasis | |||||||
| No | Ref. | Ref. | |||||
| Yes | 1.850 | 1.527–2.244 | <0.001 | 1.993 | 1.644–2.418 | <0.001 | |
OR, odds ratio; CI, confidence interval; LUAD, lung adenocarcinoma; ADSQC, adenosquamous carcinoma; SQCC, squamous cell carcinoma; LCLC, large-cell lung carcinoma.