Table 4. Multivariate logistic regression for the risk factors of early death.
| Variable | Overall early-death | Cancer-specific early-death | |||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | ||
| Age (years) | |||||||
| ≤65 | Ref. | Ref. | |||||
| 66–71 | 1.269 | 1.028–1.566 | 0.027 | 1.163 | 0.943–1.434 | 0.157 | |
| >71 | 1.537 | 1.262–1.870 | <0.001 | 1.528 | 1.258–1.856 | <0.001 | |
| Sex | |||||||
| Male | Ref. | Ref. | |||||
| Female | 0.803 | 0.679–0.949 | 0.010 | 0.873 | 0.739–1.030 | 0.108 | |
| Race | |||||||
| White | Ref. | Ref. | |||||
| Black | 0.842 | 0.653–1.084 | 0.183 | 0.829 | 0.645–1.065 | 0.144 | |
| Other | 0.691 | 0.521–0.913 | 0.010 | 0.689 | 0.520–0.909 | 0.009 | |
| Marital | |||||||
| Married | Ref. | Ref. | |||||
| Unmarried | 1.078 | 0.910–1.276 | 0.385 | 1.087 | 0.919–1.285 | 0.328 | |
| Grade | |||||||
| I | Ref. | Ref. | |||||
| II | 0.869 | 0.549–1.384 | 0.551 | 0.877 | 0.556–1.394 | 0.574 | |
| III | 1.451 | 0.932–2.278 | 0.102 | 1.484 | 0.956–2.326 | 0.081 | |
| IV | 1.827 | 0.937–3.574 | 0.077 | 2.053 | 1.061–3.990 | 0.033 | |
| Tumor size (mm) | |||||||
| ≤46 | Ref. | Ref. | |||||
| 47–70 | 0.936 | 0.766–1.144 | 0.520 | 0.928 | 0.760–1.132 | 0.462 | |
| >70 | 1.320 | 1.043–1.672 | 0.021 | 1.387 | 1.099–1.751 | 0.006 | |
| Histology | |||||||
| LUAD | Ref. | Ref. | |||||
| ADSQC | 0.913 | 0.482–1.692 | 0.775 | 1.012 | 0.539–1.864 | 0.969 | |
| SQCC | 1.619 | 1.285–2.042 | <0.001 | 1.575 | 1.254–1.978 | <0.001 | |
| LCLC | 0.807 | 0.384–1.685 | 0.568 | 0.868 | 0.417–1.797 | 0.703 | |
| Other | 1.345 | 1.056–1.712 | 0.016 | 1.317 | 1.038–1.671 | 0.023 | |
| T stage | |||||||
| T1 | Ref. | Ref. | |||||
| T2 | 1.129 | 0.823–1.554 | 0.453 | 1.242 | 0.905–1.712 | 0.182 | |
| T3 | 1.476 | 1.057–2.066 | 0.023 | 1.550 | 1.110–2.172 | 0.010 | |
| T4 | 1.592 | 1.152–2.208 | 0.005 | 1.693 | 1.225–2.350 | 0.002 | |
| N stage | |||||||
| N0 | Ref. | Ref. | |||||
| N1 | 1.155 | 0.839–1.589 | 0.376 | 1.109 | 0.806–1.523 | 0.524 | |
| N2 | 1.352 | 1.097–1.669 | 0.005 | 1.281 | 1.042–1.578 | 0.019 | |
| N3 | 1.227 | 0.942–1.598 | 0.129 | 1.234 | 0.950–1.604 | 0.115 | |
| Surgery | |||||||
| No | Ref. | Ref. | |||||
| Yes | 0.343 | 0.227–0.510 | <0.001 | 0.311 | 0.202–0.469 | <0.001 | |
| Radiation | |||||||
| No/Unknown | Ref. | Ref. | |||||
| Yes | 0.604 | 0.494–0.739 | <0.001 | 0.680 | 0.558–0.828 | <0.001 | |
| Chemotherapy | |||||||
| No/Unknown | Ref. | Ref. | |||||
| Yes | 0.116 | 0.098–0.138 | <0.001 | 0.130 | 0.109–0.155 | <0.001 | |
| Bone metastasis | |||||||
| No | Ref. | Ref. | |||||
| Yes | 1.586 | 1.319–1.910 | <0.001 | 1.640 | 1.366–1.971 | <0.001 | |
| Liver metastasis | |||||||
| No | Ref. | Ref. | |||||
| Yes | 1.654 | 1.304–2.098 | <0.001 | 1.778 | 1.407–2.249 | <0.001 | |
OR, odds ratio; CI, confidence interval; LUAD, lung adenocarcinoma; ADSQC, adenosquamous carcinoma; SQCC, squamous cell carcinoma; LCLC, large-cell lung carcinoma.