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. 2023 Mar 31;12(3):406–424. doi: 10.21037/tau-23-21

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2023 Translational Andrology and Urology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Mutation landscape and hub mutated genes in patients with advanced RCC from the CheckMate ICI therapy cohort. (A) Oncoplot for the mutated genes of 454 patients with advanced RCC from the CheckMate ICI therapy cohort. (B) PPI network of the mutated genes sorted by mutation frequencies in advanced RCC. The brighter color represented more interactions with adjacent genes. TMB, tumoral mutation burden; RCC, renal cell carcinoma; ICI, immune checkpoint inhibitor; PPI, protein–protein interaction.