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. 2023 Mar 31;12(3):406–424. doi: 10.21037/tau-23-21

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2023 Translational Andrology and Urology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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External validation of the mutation classifier in the ICI therapy and non-ICI therapy cohorts. Kaplan-Meier curves show the differences in OS between the low- and high-risk groups in the (A) MSKCC advanced RCC ICI therapy cohort, (B) MSKCC pan-cancer ICI therapy cohort, (C) CheckMate non-ICI therapy cohort, and (D) TCGA cohort. (E) Kaplan-Meier curves of OS in the MSKCC advanced RCC ICI therapy cohort according to TMB. (F,G) Kaplan-Meier curves of OS in patients from the high- and low-TMB groups in the MSKCC advanced RCC ICI therapy cohort. OS, overall survival; RCC, renal cell carcinoma; ICI, immune checkpoint inhibitor; HR, hazard ratio; MSKCC, Memorial Sloan Kettering Cancer Center; TCGA, The Cancer Genome Atlas; TMB, tumoral mutation burden.