Table 1. Patient Characteristics by Treatment Group at Enrollment, 2020-2021a.
| Characteristic | Primary cohort, No. (%) | Matched cohort, % (95% CI)b | ||||
|---|---|---|---|---|---|---|
| Traditional therapy (n = 4706) | Systemic therapy (n = 1201) | Biologic therapy (n = 2860) | Traditional therapy | Systemic therapy | Biologic therapy | |
| Sex | ||||||
| Female | 1720 (36.5) | 343 (28.6) | 887 (31.0) | 33.9 (33.5-34.3) | 29.3 (28.6-30.0) | 31.2 (30.7-31.7) |
| Male | 2983 (63.4) | 856 (71.3) | 1970 (68.9) | 66.1 (65.7-66.5) | 70.7 (70.0-71.4) | 68.8 (68.3-69.3) |
| Age, median (IQR or 95% CI), y | 36.7 (26.4-52.1) | 46.7 (32.8-57.6) | 38.9 (30.4-51.7) | 38.4 (38.4-38.5) | 38.9 (38.8-39.0) | 38.5 (38.4-38.6) |
| BMI, median (IQR or 95% CI) | 23.7 (21.3-26.2) | 24.2 (22.1-26.2) | 24.2 (22.0-26.7) | 24.0 (23.9-24.0) | 24.1 (24.0-24.2) | 24.2 (24.2-24.2) |
| Marital status | ||||||
| Married | 3325 (70.7) | 964 (80.3) | 2143 (74.9) | 75.6 (75.3-76.0) | 75.7 (74.9-76.4) | 73.8 (73.4-74.2) |
| Unmarried | 1317 (28.0) | 214 (17.8) | 670 (23.4) | 24.4 (24.0-24.7) | 24.3 (23.6-25.1) | 26.2 (25.8-26.6) |
| Employment | ||||||
| Full time | 2598 (55.2) | 663 (55.2) | 1800 (62.9) | 59.0 (58.5-59.5) | 61.2 (60.4-62.0) | 61.3 (60.8-61.7) |
| Otherc | 2045 (43.5) | 515 (42.9) | 1013 (35.4) | 41.0 (40.5-41.5) | 38.8 (38.0-39.6) | 38.7 (38.3-39.2) |
| Educational level | ||||||
| College degree or higher | 1325 (28.2) | 257 (21.4) | 1004 (35.1) | 28.1 (27.6-28.5) | 26.1 (25.3-26.9) | 35.1 (34.5-35.7) |
| High school or lower | 3318 (70.5) | 921 (76.7) | 1809 (62.3) | 71.9 (71.5-72.4) | 73.9 (73.1-74.7) | 64.9 (64.3-65.5) |
| Smoking status | ||||||
| Current | 1155 (24.5) | 338 (28.1) | 750 (26.2) | 25.5 (25.1-25.9) | 26.9 (26.0-27.7) | 24.1 (23.6-24.7) |
| Previous or nonsmoker | 3488 (74.1) | 840 (69.9) | 2063 (72.1) | 74.5 (74.1-74.9) | 73.1 (72.3-74.0) | 75.9 (75.3-76.4) |
| Psoriasis duration, median (IQR or 95% CI), y | 4 (1-11) | 6 (2-14) | 10 (4-18) | 6 (6-6) | 5 (5-5) | 6 (6-6) |
| Family history of psoriasis | ||||||
| Positive | 712 (15.1) | 159 (13.2) | 529 (18.5) | 15.6 (15.0-16.1) | 13.8 (13.0-14.6) | 17.1 (16.4-17.8) |
| Negative | 3504 (74.5) | 923 (76.9) | 2030 (71.0) | 84.4 (83.9-85.0) | 86.2 (85.4-87.0) | 82.9 (82.2-83.6) |
| Lesions on particular areas | ||||||
| Nail | ||||||
| Affected | 801 (17.0) | 346 (28.8) | 924 (32.3) | 19.4 (18.9-19.9) | 24.3 (23.6-25.0) | 25.9 (25.3-26.5) |
| Unaffected | 3719 (79.0) | 820 (68.3) | 1820 (63.6) | 80.6 (80.1-81.1) | 75.7 (75.0-76.4) | 74.1 (73.5-74.7) |
| Scalp | ||||||
| Affected | 2977 (63.3) | 775 (64.5) | 2086 (72.9) | 67.3 (66.8-67.8) | 67.2 (66.3-68.1) | 69.8 (69.2-70.4) |
| Unaffected | 1653 (35.1) | 401 (33.4) | 740 (25.9) | 32.7 (32.2-33.2) | 32.8 (31.9-33.7) | 30.2 (29.6-30.8) |
| Palmoplantar | ||||||
| Affected | 629 (13.4) | 284 (23.6) | 781 (27.3) | 15.4 (15.0-15.8) | 17.3 (16.7-18.0) | 20.2 (19.7-20.7) |
| Unaffected | 3971 (84.4) | 886 (73.8) | 2004 (70.1) | 84.6 (84.2-85.0) | 82.7 (82.0-83.3) | 79.8 (79.3-80.3) |
| Genital | ||||||
| Affected | 454 (9.6) | 156 (13.0) | 546 (19.1) | 10.7 (10.3-11.1) | 10.3 (9.7-10.8) | 14.1 (13.7-14.6) |
| Unaffected | 4115 (87.4) | 1006 (83.8) | 2217 (77.5) | 89.3 (88.9-89.7) | 89.7 (89.2-90.3) | 85.9 (85.4-86.3) |
| Disease severity, median (IQR or 95% CI) | ||||||
| PASI | 5.8 (2.7-12.0) | 10.8 (5.6-18.3) | 14.3 (7.5-21.6) | 8.8 (8.7-8.9) | 9.0 (9.0-9.0) | 9.0 (9.0-9.0) |
| BSA affected by psoriasis lesions, % | 8.0 (3.0-20.0) | 20.0 (8.0-40.0) | 21.0 (10.0-40.0) | 14.0 (13.3-14.7) | 14.4 (14.0-14.8) | 14.0 (13.3-14.7) |
| DLQI | 6 (2-10) | 9 (4-13) | 10 (5-16) | 8 (8-8) | 8 (8-8) | 8 (8-8) |
| Comorbidities | ||||||
| Positive | 653 (13.9) | 236 (19.7) | 431 (15.1) | 15.3 (14.8-15.8) | 15.9 (15.1-16.7) | 15.0 (14.4-15.6) |
| Negative | 3682 (78.2) | 871 (72.5) | 2186 (76.4) | 84.7 (84.2-85.2) | 84.1 (83.3-84.9) | 85.0 (84.4-85.6) |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); BSA, body surface area; DLQI, Dermatology Life Quality Index; PASI, Psoriasis Area and Severity Index.
a
Patients whose characteristics were missing were not counted; thus, the numbers may not sum to group total counts or to 100%.
b
Data were calculated from 20 multiple imputed data sets.
c
Other included part-time workers, students, retired participants, and unemployed participants.