Table 1.
Extrinsic and intrinsic factors impacting on survival and longevity of BMPC (alphabetical order).
| receptor interaction | ref. | metabolic features | ref. | turnover | ref. | potential Imprinting | ref. |
|---|---|---|---|---|---|---|---|
| CD138-heparan sulfate | (76–80) | AMPK-mTOR axis | (40–42, 55, 56) | age | (104, 105) | activating BCR signal strength | (49–52) |
| CD19-PI3K | (31–35) | autophagy | (46) | circadian rhythm | (95–98) | timing of immune reaction | (99) |
| CD28-CD80/86 | (67, 68) | epigenetic regulation | (25–27) | gravity | (90, 91) | TLR signaling | (122–124) |
| CDCR4-CXCL12 | (63, 64) | cytoplasmic calcium | to prove | inflammation | (81) | type and structure of antigen | (28, 29, 120, 121) |
| LFA1-ICAM1 | (65) | OXPHOS | (3, 30) | injury | (89) | ||
| TACI/BCMA-APRIL | (68–75) | oxygen partial pressure | (86, 87) | interstitial calcium | (88) | ||
| VLA4-VCAM1 | (66) | proteasome activity | (110–112) | ||||
| ROS | (69) | ||||||
| sugar import | (36, 44) | ||||||
| UPR | (47–49) |