TABLE 2.
Summary of all included scales in HD
| Scale | Developed for use in HD | Scale has been applied to HD populations | Used by other groups beyond the original developing groupa | Appropriate clinimetric testing in HD | Recommendation level | Comments |
|---|---|---|---|---|---|---|
|
| ||||||
| UHDRS-cognitive assessment | Yes | Yes | Yes | No | Suggested for assessing severity of cognitive dysfunction in HD | |
| UHDRS-FAP cognitive section | Yes | Yes | No | Yes | Suggested for assessing severity of cognitive dysfunction in late-stage HD | |
| Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) | No | Yes | Yes | No | Suggested for assessing severity of cognitive dysfunction in HD | |
| Montreal Cognitive Assessment (MoCA) | No | Yes | Yes | Yes1/no2 |
1 Recommended with caveats for assessing severity of cognitive dysfunction in HD 2Suggested for screening for presence of cognitive impairment in HD |
|
| Mattis Dementia Rating Scale (MDRS) | No | Yes | Yes | No | Suggested for assessing severity of cognitive dysfunction in HD | |
| Frontal Assessment Battery (FAB) | No | Yes | Yes | No | Suggested for assessment of severity of frontal lobe dysfunction in moderate-severe HD | |
| Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-cog) | No | Yes | Yes | No | Suggested for assessing severity of cognitive dysfunction in HD | |
| Mini-Mental State Examination (MMSE) | No | Yes | Yes | No | Suggested for assessing severity of cognitive dysfunction in moderate-severe HD | |
| HD-Cognitive Assessment Battery (HD-CAB)b | Yes | Yes | No | No | Listed | Data from ongoing clinical trials needs appraisal in the near future |
| Neuropsychiatry Unit COGnitive assessment tool (NUCOG)b | No | Yes | No | No | Listed | Very limited use |
| Wechsler Adult Intelligence Scale-Revised (WAIS-III)b | No | Yes | No | No | Listed | More recent version (WAIS-IV) has not been used in HD |
| Computerized Drug Research Cognitive Assessment System (CODGRAS/CDR)b | No | Yes | No | No | Listed | Very limited use |
| Addenbrooke’s Cognitive Examination-Revised (ACE-R)b | No | Yes | No | No | Listed | |
| Brief Cognitive Rating Scale (BCRS)b | No | Yes | No | No | Listed | Very limited use |
a
For those not developed for use in HD, if used in 1 group.
b
Note: References for scales categorized as “listed” are included in the online supplementary data.