TABLE 3.
Summary of clinimetric data of all scales used in HD with a recommendation level of “suggested” and “recommended with caveats”
| Scale | Internal consistency | Test-retest reliability | Interrater reliability | Construct validity | Discrimination across disease stages/severity | Responsiveness | Ceiling/floor effect | Sensitivity/specificity |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Unified Huntington’s Disease Rating Scale (UHDRS)-cognitive assessment | + | NR | NR | + | + | +/− | NR | NR |
| Unified Huntington’s Disease Rating Scale for Advanced Patients (UHDRS-FAP) | + | NR | + | + | NR | + | No floor or ceiling effect (for TFC ≤ 5) | NR |
| ADAS-Cognitive subscale (ADAS-cog) | NR | NR | NR | NR | NR | Ceiling effect | NR | |
| Frontal Assessment Battery (FAB) | + | NR | NR | + | + | +/− | Floor effect | NR |
| Mattis Dementia Rating Scale (MDRS) | NR | NR | NR | + | NR | + | Floor effect | +/− |
| Mini-Mental State Examination (MMSE) | NR | NR | NR | + | + | +/− | Ceiling effect | NR |
| Montreal Cognitive Assessment (MoCA) | + | + | NR | + | + | − | Ceiling effect | +/− |
| Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) | NR | NR | NR | + | R | +/− | Floor and ceiling effects | NR |
NR, not reported; +, good performance; +/−, contradictory data or very limited data; −, poor performance.
Note: data regarding minimally clinically important difference was not assessed in any of the scales.