Table 1.
Average cigarettes per day (CPD) reported at Week 12.
| Mean Difference (95% CI) | p-value1 | |
|---|---|---|
| Main effects model 1 | ||
| Cigarette Nicotine Content: VLNC (vs. NNC) | −12.96 (−21.51, −4.42) | 0.005 |
| E-Liquid Nicotine Content: Moderate (vs. Low) | −3.52 (−11.67, 4.64) | 0.383 |
| E-Liquid Flavor Availability: All Flavors (vs. Tobacco Flavors) | −2.21, (−10.21, 5.78) | 0.573 |
| Cigarette Nicotine Content x E-liquid Nicotine Content model 1 | 0.061 | |
| VLNC vs NNC, Moderate Nicotine E-liquid | −22.6 (−35.56, −9.64) | 0.001 |
| VLNC vs NNC, Low Nicotine E-liquid | −7.22 (−17.32, 2.87) | 0.152 |
| Cigarette Nicotine Content x E-liquid Flavor Availability model 1 | 0.061 | |
| VLNC vs NNC, All E-liquid Flavors | −20.81 (−32.37, −9.25) | 0.001 |
| VLNC vs NNC, Tobacco E-liquid Flavors | −7.13 (−17.29, 3.02) | 0.160 |
Normal Nicotine Content (NNC) Cigarettes: 15.8 mg nicotine per gram of tobacco
Very Low Nicotine Content (VLNC) Cigarettes: 0.4mg nicotine per gram of tobacco
Moderate Nicotine E-liquid: 1.8% free-base nicotine
Low Nicotine E-liquid: 0.3% free-base nicotine
All E-liquid Flavors: 12 flavors available to choose from, including: robust tobacco, light tobacco, tobacco/menthol blend, mixed berry, watermelon, berry, cookies and crème, chocolate, caramel, spearmint, peppermint, and menthol.
Tobacco E-liquid Flavors: 3 flavors available to choose from, including: robust tobacco, light tobacco, tobacco/menthol blend.
1
adjusted for baseline CPD, site, menthol status, and age group