Table 3.
Summary of lipid metabolites associated with total PFAS and individual PFAS in VDAART mothers.
| VDAART Mothers | |||||||
|---|---|---|---|---|---|---|---|
| PFAS mixture | Individual PFAS | ||||||
| Lipid Sub-Pathway | Number of Metabolites | Number in Pathway | % Significant in Pathway | Number of Total Associations | Number of Unique Metabolites | Number in Pathway | % Significant in Pathway |
| Sphingomyelins | 29 | 35 | 11 | 29 | 37.93 | ||
| Fatty Acid, Dicarboxylate | 3 | 27 | 11.11 | 12 | 5 | 27 | 18.52 |
| Fatty Acid, Monohydroxy | 16 | 8 | 3 | 16 | 18.75 | ||
| Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 4 | 16 | 25 | 6 | 4 | 16 | 25 |
| Progestin Steroids | 7 | 5 | 2 | 7 | 28.57 | ||
| Fatty Acid Metabolism (also BCAA Metabolism) | 1 | 4 | 25 | 4 | 1 | 4 | 25 |
| Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | 10 | 3 | 2 | 10 | 20 | ||
| Diacylglycerol | 1 | 3 | 33.33 | 3 | 2 | 3 | 66.67 |
| Hexosylceramides (HCER) | 4 | 2 | 2 | 4 | 50 | ||
| Fatty Acid Metabolism (Acyl Choline) | 9 | 2 | 1 | 9 | 11.11 | ||
| Ceramides | 4 | 2 | 2 | 4 | 50 | ||
| Sterol | 5 | 1 | 1 | 5 | 20 | ||
| Phospholipid Metabolism | 7 | 1 | 1 | 7 | 14.29 | ||
| Phosphatidylethanolamine (PE) | 1 | 12 | 8.33 | 1 | 1 | 12 | 8.33 |
| Medium Chain Fatty Acid | 9 | 1 | 1 | 9 | 11.11 | ||
| Long Chain Saturated Fatty Acid | 7 | 1 | 1 | 7 | 14.29 | ||
| Fatty Acid Synthesis | 2 | 1 | 1 | 2 | 50 | ||
| Fatty Acid Metabolism (Acyl Carnitine, Polyunsaturated) | 1 | 6 | 16.67 | 1 | 1 | 6 | 16.67 |
| Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 8 | 1 | 1 | 8 | 12.5 | ||
The number of lipid metabolites significantly associated with PFAS mixture or one of the six individual PFAS species are summarized by lipid sub-pathway. For associations with PFAS mixture, the number of metabolites with associations that met an FDR<0.05 threshold, total number of metabolites tested in the sub-pathway (significant and non-significant), and the percent of significant metabolites within a pathway are shown for each lipid sub-pathway. For associations with individual PFAS, the number of metabolite associations that met an FDR<0.05 threshold, number of unique metabolites that produced associations, total number of metabolites tested in the sub-pathway (significant and non-significant), and the percent of significant metabolites within a pathway are shown for each lipid sub-pathway. Sub-pathways with no significant associations are colored in grey.