Table 4.
Summary of lipid metabolites associated with total PFAS or individual PFAS in VDAART children.
| VDAART Children | |||||||
|---|---|---|---|---|---|---|---|
| PFAS mixture | Individual PFAS | ||||||
| Lipid Sub-Pathway | Number of Metabolites | Number in Pathway | % Significant in Pathway | Number of Total Associatio ns | Number of Unique Metabolite s | Number in Pathway | % Significant in Pathway |
| Phosphatidylcholine (PC) | 9 | 14 | 64.29 | 32 | 10 | 19 | 52.63 |
| Lysophospholipid | 9 | 19 | 47.37 | 28 | 10 | 26 | 38.46 |
| Sphingomyelins | 8 | 29 | 27.59 | 20 | 8 | 29 | 27.59 |
| Phosphatidylinositol (PI) | 3 | 6 | 50 | 9 | 3 | 6 | 50 |
| Fatty Acid, Dicarboxylate | 2 | 27 | 7.41 | 9 | 6 | 27 | 22.22 |
| Long Chain Polyunsaturated Fatty Acid (n3 and n6) | 6 | 15 | 40 | 7 | 6 | 15 | 40 |
| Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated) | 3 | 8 | 37.5 | 7 | 3 | 8 | 37.5 |
| Plasmalogen | 2 | 11 | 18.18 | 4 | 2 | 11 | 18.18 |
| Lysoplasmalogen | 4 | 4 | 100 | 4 | 4 | 4 | 100 |
| Fatty Acid, Monohydroxy | 1 | 16 | 6.25 | 4 | 3 | 16 | 18.75 |
| Dihydrosphingomyelins | 1 | 5 | 20 | 4 | 1 | 5 | 20 |
| Phosphatidylethanolamine (PE) | 1 | 12 | 8.33 | 3 | 1 | 12 | 8.33 |
| Long Chain Saturated Fatty Acid | 2 | 7 | 28.57 | 3 | 3 | 7 | 42.86 |
| Carnitine Metabolism | 1 | 2 | 50 | 3 | 1 | 2 | 50 |
| Androgenic Steroids | 14 | 3 | 3 | 14 | 21.43 | ||
| Progestin Steroids | 1 | 5 | 20 | 2 | 1 | 5 | 20 |
| Primary Bile Acid Metabolism | 10 | 2 | 2 | 10 | 20 | ||
| Pregnenolone Steroids | 2 | 6 | 33.33 | 2 | 2 | 6 | 33.33 |
| Fatty Acid, Dihydroxy | 1 | 5 | 20 | 2 | 1 | 5 | 20 |
| Fatty Acid, Branched | 1 | 4 | 25 | 2 | 1 | 4 | 25 |
| Fatty Acid, Amino | 1 | 3 | 33.33 | 2 | 1 | 3 | 33.33 |
| Fatty Acid Metabolism (Acyl Carnitine, Monounsaturated) | 4 | 2 | 1 | 10 | 10 | ||
| Ceramides | 2 | 2 | 2 | 4 | 50 | ||
| Sphingosines | 1 | 2 | 50 | 1 | 1 | 2 | 50 |
| Phospholipid Metabolism | 1 | 7 | 14.29 | 1 | 1 | 7 | 14.29 |
| Mevalonate Metabolism | 1 | 1 | 100 | 1 | 1 | 1 | 100 |
| Medium Chain Fatty Acid | 1 | 9 | 11.11 | 1 | 1 | 9 | 11.11 |
| Eicosanoid | 1 | 1 | 100 | 1 | 1 | 1 | 100 |
The number of lipid metabolites significantly associated (FDR<0.05) with PFAS mixture or one of the six individual PFAS species are summarized by lipid sub-pathway. Categorization is consistent with Table 3.