Table 5.
Summary of amino acid metabolites associated with total PFAS or individual PFAS in VDAART mothers.
| VDAART Mothers | |||||||
|---|---|---|---|---|---|---|---|
| PFAS mixture | Individual PFAS | ||||||
| Amino Acid Sub-Pathway | Number of Metabolites | Number in Pathway | % Significant in Pathway | Number of Total Associations | Number of Unique Metabolites | Number in Pathway | % Significant in Pathway |
| Leucine, Isoleucine and Valine Metabolism | 31 | 8 | 4 | 31 | 12.9 | ||
| Tryptophan Metabolism | 18 | 5 | 3 | 18 | 16.67 | ||
| Methionine, Cysteine, SAM and Taurine Metabolism | 1 | 20 | 5 | 5 | 3 | 20 | 15 |
| Glycine, Serine and Threonine Metabolism | 1 | 10 | 10 | 5 | 2 | 10 | 20 |
| Tyrosine Metabolism | 14 | 2 | 1 | 14 | 7.14 | ||
| Histidine Metabolism | 14 | 2 | 2 | 14 | 14.29 | ||
| Glutamate Metabolism | 12 | 1 | 1 | 12 | 8.33 | ||
| Alanine and Aspartate Metabolism | 9 | 1 | 1 | 9 | 11.11 | ||
The number of amino acid metabolites significantly associated (FDR<0.05) with PFAS mixture or one of the six individual PFAS species are summarized by amino acid sub-pathway. Categorization is consistent with Table 3.