Table 6.
Summary of amino acid metabolites associated with total PFAS or individual PFAS in VDAART children.
| VDAART Children | |||||||
|---|---|---|---|---|---|---|---|
| PFAS mixture | Individual PFAS | ||||||
| Amino Acid Sub-Pathway | Number of Metabolites | Number in Pathway | % Significant in Pathway | Number of Total Associations | Number of Unique Metabolites | Number in Pathway | % Significant in Pathway |
| Urea cycle; Arginine and Proline Metabolism | 3 | 21 | 14.29 | 12 | 5 | 21 | 23.81 |
| Leucine, Isoleucine and Valine Metabolism | 30 | 5 | 3 | 30 | 10 | ||
| Glutamate Metabolism | 1 | 12 | 8.33 | 4 | 2 | 12 | 16.67 |
| Glycine, Serine and Threonine Metabolism | 1 | 10 | 10 | 3 | 2 | 10 | 20 |
| Alanine and Aspartate Metabolism | 2 | 9 | 22.22 | 3 | 2 | 9 | 22.22 |
| Tryptophan Metabolism | 1 | 17 | 5.88 | 2 | 2 | 17 | 11.76 |
| Lysine Metabolism | 17 | 1 | 1 | 17 | 5.88 | ||
| Histidine Metabolism | 15 | 1 | 1 | 15 | 6.67 | ||
| Glutathione Metabolism | 1 | 7 | 14.29 | 1 | 1 | 7 | 14.29 |
| Creatine Metabolism | 3 | 1 | 1 | 3 | 33.33 | ||
The number of amino acid metabolites significantly associated (FDR<0.05) with PFAS mixture or one of the six individual PFAS species are summarized by amino acid sub-pathway. Categorization is consistent with Table 3.