| Date of search |
December 3, 2021 |
| Databases and other sources searched |
PubMed, Embase, and Cochrane Library were searched. Important missed citations in the literature were searched for manually |
| Search terms used |
Denosumab, child, adolescent, pediatric, giant cell tumor of bone, osteogenesis imperfecta, fibrous dysplasia, aneurysmal bone cyst |
| Timeframe |
From the establishment of database to December 3, 2021 |
| Inclusion and exclusion criteria |
Inclusion criteria: studies of applying denosumab in children younger than 18 years old; in the English language; and including case and series reports, retrospective cohort studies, and prospective studies |
| Exclusion criteria: lack of a detailed description of how to use denosumab and no data on effects or complications |
| Selection process |
Daoxi Wang and Qianyu Shi conducted the selection independently and then worked cooperatively in the literature screening. When there was disagreement on a piece of literature, third experts (Tao Ji or Xueyang Tang) was consulted |
