Table 3. Characteristics of patients according to C3dg and/or MAC deposition.
| Variables | Both C3dg and MAC deposition (n=40) | Only C3dg deposition (n=8) | Only MAC deposition (n=8) | No C3dg and MAC deposition (n=22) |
|---|---|---|---|---|
| Clinical characteristics | ||||
| Serum creatinine (μmol/L) | 67.3±21.3 | 56.4±13.9 | 46.9±13.5* (P=0.004) | 48.3±11.4* (P<0.001) |
| BUN (mmol/L) | 7.9±5.2 | 12.8±17.6 | 9.5±7.0 | 5.6±2.2# (P=0.016) |
| Urinary protein (g/24 h) | 3.4±2.1 | 0.9±1.1* (P=0.002) | 2.0±3.6 | 0.3±0.2* (P<0.001)& (P=0.034) |
| Serum C3 (g/L) | 0.5±0.2 | 0.7±0.4* (P=0.015) | 0.9±0.5* (P<0.001) | 0.72±0.23* (P<0.001) |
| Serum C4 (g/L) | 0.1±0.1 | 0.3±0.2* (P<0.001) | 0.2±0.2* (P=0.002) | 0.2±0.1* (P=0.004)# (P=0.032) |
| eGFR (mL/min/1.73 m2) | 119.1±36.3 | 136.4±32.4 | 155.1±53.2* (P=0.018) | 157.8±38.2* (P<0.001) |
| Urinary RBC (unit/HP) | 75.4±77.7 | 26.5±49.1 12.86±33.91* (P=0.049) |
43.1±49.4 | 12.9±33.9* (P<0.001) |
| Urinary WBC (unit/HP) | 19.5±26.0 | 2.3±1.8* (P=0.0031) | 12.0±23.5 | 2.1±1.6 * (P=0.002) |
| SLEDAI | 19.1±5.6 | 13.9±8.8* (P=0.043) | 15.6±8.3* (P=0.043) | 9.9±6.5* (P<0.001)& (P=0.036) |
| Pathological characteristics | ||||
| Activity indices score | 10.5±3.1 | 5.5±2.4* (P<0.001) | 6.3±2.3* (P<0.001) | 4.6±2.0* (P<0.001) |
| Endocapillary hypercellularity | 2.8±0.4 | 2.00±0.75* (P<0.001) | 1.9±0.6* (P<0.001) | 1.0±0.2* (P<0.001)# (P<0.001)& (P<0.001) |
| Cellular crescents | 3.4±1.4 | 1.0±1.5 * (P<0.001) |
1.3±1.5* (P<0.001) | 0* (P<0.001)# (P=0.047)& (P=0.014) |
| Karyorrhexis/fibrinoid necrosis | 0.8±1.1 | 0.3±0.71 | 1.0±1.5 | 0.5±0.9 |
| Subendothelial hyaline deposits | 0.7±0.8 | 0.5±0.5 | 0.1±0.4 | 0.5±0.5 * (P=0.038) |
| Interstitial inflammatory cell infiltration | 1.5±0.7 | 1.0±0.5* (P=0.035) | 1.0±0.0* (P=0.035) | 1.5±0.6 |
| Glomerular leukocyte infiltration | 1.4±0.8 | 0.8±0.5* (P=0.029) | 1.0±0.5 | 1.2±0.6 |
| Chronicity indices score | 0.9±1.4 | 1.9±1.6 | 1.4±1.7 | 1.0±1.5 |
| Glomerular sclerosis | 0.3±0.6 | 0.8±0.7 | 0.4±0.5 | 0.3±0.7 |
| Fibrous crescents | 0.4±0.6 | 0.3±0.5 | 0.4±0.5 | 0.2±0.4 |
| Tubular atrophy | 0.1±0.3 | 0.4±0.5* (P=0.021) | 0.3±0.5 | 0.1±0.3 |
| Interstitial fibrosis | 0.2±0.4 | 0.5±0.5 | 0.4±0.5 | 0.4±0.6 |
Data were presented as mean ± SD. *, compared to the combined C3dg and MAC deposition group; #, compared to the only C3dg deposition group; &, Compared to the only MAC deposition group. MAC, membrane attack complex; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; RBC, red blood cell; WBC, white blood cell; SLEDAI, systemic lupus erythematosus disease activity index.