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. 2023 Apr 7;13:5707. doi: 10.1038/s41598-023-32745-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gross pathology of the lung (A) and pathologic analysis using HE-stained lung specimens (B–E). (A) The representative photographs of the lung in the normal mice (upper panel) and IP mouse models treated with MTX for 1 week (middle panel) and 2 weeks (bottom panel). Left panel: Con group or Con-IP group; right panel: Si group or Si-IP group. (B,C) The representative microphotographs of the HE-stained lung in the normal mice (upper panel) and IP mouse models treated with MTX for 1 week (middle panel) and 2 weeks (bottom panel). (B) Con group or Con-IP group (C) Si group or Si-IP group. Left panel: low magnification; right panel: high magnification. Scale bar 200 µm (B,C: left); 100 µm (B,C: right). (D,E) The measured results of interstitial area in the lung. (D) Bar chart indicates the mean values. (E) The dot graph indicates the individual values. White: Control group. Black: Si-based agent group. MTX administration for 1 week (left pair graph) and 2 weeks (right pair graph). Data are expressed as mean. SEM of eight mice per group. **p < 0.01 vs. Control group, determined by Student’s paired t-test.