Table 1.

Analytical comparison results of Con-IP and Si-IP group.

Method	Target	1 week model	2 weeks model
Macroscopic findings	Pulmonary abnormalities (e.g., haemorrhage and congestion)	No difference
HE staining	Interstitial hypertrophy	Control > Si = normal	Control > Si = normal
Masson’s trichrome staining	Collagen fibers in interstitium	Control > Si = normal	Control > Si = normal
Immunofluorescent staining	α-SMA expression in interstitium (α-SMA)	Control > Si	Control > Si
	The number of neutrophils (Gr-1)	Control > Si	Control > Si
	The number of macrophage cells (F4/80)	Control > Si	Control > Si