Fig. 4. Stratified analysis of adjusted excess burden of post-acute sequelae of SARS-CoV-2 infection (PASC) over different subgroups, the INSIGHT cohort, from March 2020 to November 2021.

The adjusted excess burden is measured by the difference in the adjusted cumulative incidence per 1000 between two exposure subgroups. Subgroups were stratified by their acute severity status, age groups, gender, race groups, and baseline pre-existing conditions. Different color panels represent different organ systems, including (from top to bottom): the nervous system, skin, respiratory system, circulatory system, blood-forming organs, endocrine and metabolic, digestive system, genitourinary system, and general signs. CAD coronary artery disease, CKD chronic kidney disease, CPD chronic pulmonary disease, T2D diabetes type 2, Healthy: no documented pre-existing conditions and no PASC-like symptoms at baseline. Two ICD-10 diagnosis codes B948 (sequelae of other specified infectious and parasitic diseases) and U099 (post-COVID-19 condition, unspecified) were also used to compare general post-acute sequelae of SARS-CoV-2 infection in different groups. The conditions with their aHRs’ P-value < 8.39 × 10⁻⁵ (the Bonferroni-corrected significance threshold) were highlighted in red squares. The PASC conditions also identified in OneFlorida+ were marked by ‡ symbols. The fraction of the subgroup population was shown at the top.