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. 2023 Mar 16;15(3):133–145. doi: 10.4253/wjge.v15.i3.133

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Functioning of simethicone at the level of the intestinal mucosa. Simethicone is a surfactant causing a reduction in the surface tension of intestinal bubbles. This reduction results in the aggregate of bubbles adhering to the colic mucosa being weaker with the facilitation of bubble reduction. As a result, larger bubbles are divided into smaller bubbles that have a greater ease of intestinal transit. The silicon dioxide component of dimethicone has an additional role, with an extensive molecular surface area that can promote bubble rupture. The breakdown of foam and bubbles and formed gas can be either absorbed by the intestinal wall or eliminated by intestinal transit. This likely explains the ameliorative effect on patients' symptoms.