Table 5.

Summarizes the updated diagnostic investigations and treatments for children with suspected GERD

Novel diagnosis tools	Treatment
Combined Video-MII-pH monitoring test to increase the detection of symptom associated reflux	Non-pharmacological treatment
	Supine 40-degree anti-Trendelenburg position
	Using the updated Cow Milk Symptom Score (CoMiSS) before and after therapeutic trial for CMPA
Esophageal manometry with pH-MII monitoring	Pharmacological treatment
	Novel prokinetics ex. mosapride, itopride, prucalopride and renzapride
Electrogastrography	Alginate antacid
	Esophageal mucosal protection: sucralfate, EsoxxTM
	Probiotics
Therapeutic trial with transpyloric feeding	Endoscopic treatment
	Transoral incisionless fundoplication

CMPA: Cow’s milk protein allergy; CoMiSS: Cow Milk Symptom Score.