Table 1. Demographics of CSF Samplesa.
| AD-DEM (N = 47) | AD-MCI (N = 63) | AD-Asymp (N = 23) | HC (N = 32) | Total (N = 165) | |
|---|---|---|---|---|---|
| Age (years) | |||||
| Mean (SD) | 68.9 (9.67) | 68.7 (8.45) | 72.8 (8.60) | 65.7 (7.90) | 68.7 (8.89) |
| Sex | |||||
| Female | 20.0 (42.6%) | 29.0 (46.0%) | 14.0 (60.9%) | 14.0 (43.8%) | 77.0 (46.7%) |
| Aβ42/Aβ40 | |||||
| Mean (SD) | 0.050 (0.013) | 0.047 (0.012) | 0.049 (0.015) | 0.128 (0.038) | 0.064 (0.037) |
| pTau 181 (pg/mL) | |||||
| Mean (SD) | 123 (48.2) | 107 (35.1) | 64.1 (29.7) | 28.0 (6.75) | 91.4 (50.3) |
| Total Tau (pg/mL) | |||||
| Mean (SD) | 568 (263) | 504 (154) | 336 (146) | 191 (46.6) | 438 (227) |
| MoCA | |||||
| Mean (SD, n) | 14.3 (6, 15) | 21.2 (4.7, 29) | 26 (NA, 1) | 27.7 (2.1, 19) | 21.6 (6.5, 64) |
| MMSE | |||||
| Mean (SD, n) | 21.6 (3.8, 8) | 25.1 (2.9,11) | 29 (NA, 1) | 30 (NA, 1) | 24.2 (3.9, 21) |
a
Because samples are selected from cohorts with varying cognitive testing measures, there is no uniform cognitive score across the cohort. The MoCA and MMSE scores that are available are presented to show the average cognitive status of each group.