Table 1. KPC-2 Steady-State Kineticsa.
| antibiotic | class | kcat (s–1) | KM (μM) | kcat/KM (μM–1 s–1) | Ki (μM) | ref |
|---|---|---|---|---|---|---|
| ampicillin | penicillin | 82 (3.9) | 270 (45) | 0.30 (0.052) | this work | |
| cefalothin | cephalosporin | 110 (2.8) | 42 (3.4) | 2.7 (0.23) | this work | |
| cefotaxime | cephalosporin | 76 (6.6) | 200 (29) | 0.38 (0.064) | (13) | |
| ceftazidime | cephalosporin | 1.9 (0.12) | 530 (69) | 0.0035 (5.2 x 10–4) | (13) | |
| faropenem | penem | 3.71 (0.21) | 16.6 (3.84) | 0.22 (0.053) | 44.1 (25.0) | (56) |
| imipenem | carbapenem | 22 (0.43) | 72 (3.2) | 0.31 (0.015) | this work | |
| meropenem | carbapenem | 21 (0.12) | 7.1 (1.0) | 3.00 (0.42) | 500 (140) | this work |
| ertapenem | carbapenem | 8.0 (0.26) | 8.6 (0.90) | 0.92 (0.10) | 710 (100) | this work |
a
Standard errors are in parentheses.