Table 5.
Inhibitory effects of crude centipede peptides on HepG2 cells in different conditions
| Concentration (mg/mL) |
Suppression ratio (%)
|
||||||||
|
Group 1
|
Group 2
|
Group 3
|
Group 4
|
Group 5
|
Group 6
|
Group 7
|
Group 8
|
Group 9
|
|
| 0.039 | 12.510 | 6.880 | 12.070 | 5.394 | 3.389 | 3.213 | 0.570 | 1.641 | 7.094 |
| 0.078 | 22.270 | 11.240 | 13.060 | 16.430 | 12.890 | 4.709 | 2.280 | 4.540 | 9.883 |
| 0.156 | 45.770 | 36.430 | 45.680 | 52.290 | 18.610 | 16.620 | 26.110 | 11.540 | 33.170 |
| 0.3125 | 85.510 | 85.040 | 88.540 | 94.360 | 68.110 | 63.660 | 58.500 | 64.170 | 76.610 |
| 0.625 | 89.090 | 86.060 | 92.440 | 94.520 | 94.170 | 94.96 | 83.200 | 95.180 | 94.570 |
| 1.250 | 91.840 | 87.490 | 93.050 | 94.770 | 96.780 | 95.730 | 94.660 | 95.300 | 96.000 |
| 2.500 | 92.070 | 89.470 | 93.430 | 94.690 | 96.940 | 96.670 | 95.540 | 95.670 | 96.920 |
| 5.000 | 92.750 | 92.000 | 95.800 | 96.680 | 97.720 | 97.780 | 95.880 | 95.790 | 97.650 |
| IC50 (mg/mL) | 0.457 | 0.310 | 0.480 | 0.360 | 0.584 | 0.681 | 0.812 | 0.757 | 0.278 |
| Extract ratio (%) | 4.550 | 5.860 | 4.320 | 5.630 | 4.210 | 3.980 | 3.340 | 3.680 | 5.940 |