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. 2023 Apr 6;23:319. doi: 10.1186/s12885-023-10804-7

Table 2.

Overall survival analyses according to delta RDW in 594 patients with ESCC

Variables Univariate Multivariate
HR 95% CI P value HR 95% CI P value
delta RDW(≥ 0.44 vs.<0.44) 1.337 1.014–1.762 0.039 1.356 1.025–1.793 0.033
Sex (male vs.female) 1.204 0.793–1.829 0.383
Age (> 60 vs.≤60) 1.157 0.880–1.520 0.297
Pathology grade
Well differentiated 0.154 0.019–1.225 0.077
middle differentiated 0.260 0.036–1.871 0.181
Poorly differentiated 0.384 0.053–2.779 0.343
Undifferentiated 1.000
Depth of tumor
T1a–1b 0.486 0.257–0.920 0.027 0.524 0.225–1.217 0.133
T2 0.593 0.404–0.869 0.007 0.567 0.292–1.099 0.093
T3 1.000
Lymph node metastasis
N0 0.134 0.087–0.204 < 0.001 0.099 0.034–0.287 < 0.001
N1 0.250 0.167–0.375 < 0.001 0.263 0.171–0.405 < 0.001
N2 0.414 0.269–0.635 < 0.001 0.448 0.291–0.689 < 0.001
N3 1.000
Pathological stage
1a–1b 0.310 0.190–0.507 < 0.001 2.632 0.573–12.092 0.213
2a–2b 0.386 0.278–0.536 < 0.001 1.468 0.602–3.581 0.399
3a–3c 1.000
Vessel invasive (absence vs. presence) 1.808 1.369–2.388 < 0.001 1.194 0.884–1.612 0.248
Nerve infiltration (absence vs. presence) 1.899 1.447–2.493 < 0.001 1.483 1.112–1.977 0.007
Treatment regimen
S 1.131 0.692–1.848 0.623
 S + postoperative C 1.327 0.777–2.269 0.300
 S + postoperative CRT 1.000
delta NLR 1.016 0.973–1.061 0.473
delta PNI 1.008 0.986–1.030 0.499

Abbreviations: S, surgery; C, chemotherapy; CRT, chemoradiotherapy