Table 5.

Risk factors associated with hypertension

Variables		Univariate OR (95% CI)	P values	Multivariate OR (95% CI)	P values#
Age (≥ 60/<60)		1.050(0.882–1.250)	0.580	0.920(0.767–1.103)	0.368
Gender (Male/Female)		0.810(0.689–0.952)	0.010	0.965(0.808–1.153)	0.698
History of smoking (Yes/No)		0.743(0.633–0.872)	< 0.001	0.764(0.636–0.918)	0.004
History of alcohol consumption (Yes/No)		0.996(0.696–1.425)	0.982	1.154(0.796–1.672)	0.449
CYP2C19
Genotype	*1/*1	1.000(reference)		1.000(reference)
	*1/*2	1.537(1.304–1.811)	< 0.001	1.529(1.296–1.803)	< 0.001
	*1/*3	1.442(1.049–1.983)	0.024	1.423(1.034–1.960)	0.030
	*2/*2	2.441(1.806–3.301)	< 0.001	2.433(1.797–3.293)	< 0.001
	*2/*3	1.546(0.989–2.417)	0.056	1.542(0.985–2.414)	0.058
	*3/*3	1.309(0.312–5.503)	0.713	1.314(0.311–5.546)	0.708
Phenotype	Extensive metabolizer	1.000(reference)		1.000(reference)
	Intermediate metabolizer	1.523(1.300-1.785)	< 0.001	1.514(1.291–1.774)	< 0.001
	Poor metabolizer	2.127(1.645–2.749)	< 0.001	2.119(1.637–2.743)	< 0.001
	Intermediate metabolizer + Poor metabolizer	1.627(1.400-1.892)	< 0.001	1.617(1.390–1.881)	< 0.001

^#P values are estimated by logistic regression adjusted for gender, age, smoking, and drinking