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. 2023 Apr 6;24:67. doi: 10.1186/s13059-023-02918-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Comprehensive m⁶A landscape during mouse MZT. a Schematic diagram of sample collection and SLIM-seq procedure. b Heatmap showing the pairwise correlations of m⁶A and mRNA expression profiles. c The numbers of m⁶A-tagged mRNAs and total mRNAs in different stages. d Boxplot plots displaying the log2 normalized m⁶A levels and mRNA expression levels in different stages. e The Sankey diagram showing the dynamics of m⁶A tagged mRNAs. Red represents the gene defined as m⁶A-tagged mRNAs cross different stages of MZT. f Venn diagram showing overlapping of m⁶A tagged genes from different stages. g Heatmap showing normalized m⁶A levels and the corresponding mRNA expression levels in different stages. h Gene ontology (GO) enrichment analysis of three types of the m⁶A tagged genes. For maternal loss, 453 genes with decrease at both m⁶A and mRNA levels are used for analysis. For de novo gain, 628 genes with increase at both m⁶A and mRNA levels are used for analysis. i Heatmap showing normalized m⁶A levels and the corresponding mRNA expression levels in ZGA