Table 2.
Association between clinicopathological characteristics with the p53 staining in hypopharyngeal squamous cell carcinoma patients
| Variable | p53 in total HPSCC (n=97) | p53 in HPV(+) HPSCC (n=15) | p53 in HPV(-) HPSCC (n=82) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Low | High | p value | Low | High | p value | Low | High | p value | |
| Age (years) | 0.9263 | 0.5804 | 0.6342 | ||||||
| ≤60 | 26 | 27 | 4 | 5 | 22 | 22 | |||
| >60 | 22 | 22 | 1 | 5 | 21 | 17 | |||
| Smoking | 0.4495 | >0.9999 | 0.6439 | ||||||
| No | 14 | 11 | 1 | 1 | 13 | 10 | |||
| Yes | 34 | 38 | 4 | 9 | 30 | 29 | |||
| Drinking | 0.9432 | 0.3333 | 0.6231 | ||||||
| No | 16 | 16 | 1 | 0 | 15 | 16 | |||
| Yes | 32 | 33 | 4 | 10 | 27 | 23 | |||
| Tumor site | 0.3502 | >0.9999 | 0.3960 | ||||||
| Pyriform sinus | 40 | 44 | 4 | 8 | 36 | 36 | |||
| Not pyriform sinus | 8 | 5 | 1 | 2 | 7 | 3 | |||
| cT stage | 0.2651 | 0.3287 | 0.5071 | ||||||
| T1-2 | 26 | 21 | 3 | 3 | 23 | 18 | |||
| T3-4 | 22 | 28 | 2 | 7 | 20 | 21 | |||
| cN stage | 0.3756 | 0.5238 | 0.3083 | ||||||
| N0 | 9 | 6 | 0 | 2 | 9 | 4 | |||
| N1-3 | 39 | 43 | 5 | 8 | 34 | 35 | |||
| Clinical stage | 0.9811 | >0.9999 | 0.6795 | ||||||
| I+II | 3 | 2 | 0 | 1 | 3 | 1 | |||
| III+IV | 45 | 47 | 5 | 9 | 40 | 38 | |||
| pT stage | 0.0528 | 0.0769 | 0.2484 | ||||||
| T1-2 | 25 | 16 | 3 | 1 | 22 | 15 | |||
| T3-4 | 23 | 33 | 2 | 9 | 21 | 24 | |||
| pN stage | 0.2133 | 0.5055 | 0.6044 | ||||||
| N0 | 3 | 8 | 0 | 3 | 3 | 5 | |||
| N1-3 | 45 | 41 | 5 | 7 | 40 | 34 | |||
| Pathological stage | 0.3772 | >0.9999 | 0.2089 | ||||||
| I+II+III | 10 | 14 | 0 | 0 | 10 | 14 | |||
| IV | 38 | 35 | 5 | 10 | 33 | 25 | |||
| Tumor differentiation | 0.5045 | >0.9999 | 0.6044 | ||||||
| Well+ well-moderately | 3 | 6 | 0 | 1 | 3 | 5 | |||
| Moderately+ Moderately-poorly | 45 | 43 | 5 | 9 | 40 | 34 | |||
| Surgical margin status | 0.4765 | >0.9999 | 0.2700 | ||||||
| ≥0.5 cm | 26 | 23 | 3 | 6 | 23 | 17 | |||
| <0.5 cm | 22 | 26 | 2 | 4 | 20 | 24 | |||
| Tumor size (cm) | 0.1135 | 0.5604 | 0.3098 | ||||||
| ≤3.5 | 33 | 26 | 2 | 2 | 31 | 24 | |||
| >3.5 | 15 | 23 | 3 | 8 | 12 | 15 | |||
| Lymph nodal fusion | 0.5244 | >0.9999 | 0.6136 | ||||||
| No | 37 | 35 | 3 | 6 | 34 | 29 | |||
| Yes | 11 | 14 | 2 | 4 | 9 | 10 | |||
| Metastatic lymph node size (cm) | 0.7256 | >0.9999 | 0.9405 | ||||||
| ≤3 | 32 | 31 | 3 | 5 | 29 | 26 | |||
| >3 | 16 | 18 | 2 | 5 | 14 | 13 | |||
| Cervical nodal necrosis | 0.9263 | 0.1009 | 0.7097 | ||||||
| No | 26 | 27 | 0 | 5 | 26 | 22 | |||
| Yes | 22 | 22 | 5 | 5 | 17 | 17 | |||
| Lymphovascular invasion | 0.9741 | 0.3333 | 0.8203 | ||||||
| No | 43 | 45 | 4 | 10 | 39 | 35 | |||
| Yes | 5 | 4 | 1 | 0 | 4 | 4 | |||
| Extracapsular spread | 0.2555 | >0.9999 | 0.2963 | ||||||
| No | 39 | 35 | 3 | 6 | 36 | 29 | |||
| Yes | 9 | 14 | 2 | 4 | 7 | 10 | |||
| Fixation of hemilarynx | 0.4790 | >0.9999 | 0.2368 | ||||||
| No | 25 | 22 | 4 | 8 | 21 | 14 | |||
| Yes | 23 | 27 | 1 | 2 | 22 | 25 | |||
| Thyroid gland invasion | 0.1173 | >0.9999 | 0.2505 | ||||||
| No | 45 | 49 | 5 | 15 | 40 | 34 | |||
| Yes | 3 | 0 | 0 | 0 | 3 | 0 | |||
| Laryngeal invasion | 0.6188 | 0.6084 | 0.7539 | ||||||
| No | 21 | 19 | 3 | 4 | 18 | 15 | |||
| Yes | 27 | 30 | 2 | 6 | 25 | 24 | |||