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. Author manuscript; available in PMC: 2023 Apr 7.
Published in final edited form as: Neurobiol Dis. 2022 Jul 26;172:105834. doi: 10.1016/j.nbd.2022.105834

Fig. 3.

Fig. 3.

Increased Arc protein correlates with a decrease in mGluR5, but not GluN1 or GluA1. (A, B) Immunoblots and quantification of hippocampal proteins show increases in Arc and c-Fos at the 40% timepoint post-prion exposure. (C, D) Immunoblots and quantification of synapse-associated proteins, including receptors (mGluR5, GluN1, and GluA1), a presynaptic protein (SNAP25), and a postsynaptic protein (PSD-95) reveal a decrease in mGluR5 dimers, and a modest increase in PSD-95. (E) qRT-PCR reveals no change in Grm5 transcripts. * and $ indicate the same GAPDH loading controls for proteins immunoblotted on the same membrane. n = 3 male mice per group. Welch’s t-test, *P ≤ 0.05; **P ≤ 0.01.