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. Author manuscript; available in PMC: 2023 Apr 7.
Published in final edited form as: Neurobiol Dis. 2022 Jul 26;172:105834. doi: 10.1016/j.nbd.2022.105834

Fig. 4.

Fig. 4.

Longitudinal study of IEGs and synaptic proteins in the prion-infected hippocampus. (A) Schematic shows the four timepoints used to interrogate disease-associated protein alterations in the brain. (B, C) Western blot and quantification of IEGs and synaptic proteins, including receptors (mGluR5, GluN1, and GluA1). & indicates the same GAPDH loading controls for proteins immunoblotted on the same membrane. n = 3 – 4 male mice per group, One-way ANOVA and Tukey HSD post hoc test; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001. (D) TEM images of the CA1 region of the hippocampus, arrowheads = post synapse density; * = lysosome, scale bar = 500 nm.