Table 6.

Kinetic values of OXA-48 β-lactamase against β-lactam antibiotics.

	kcat (s−1)	Km (µM)	kcat/Km (mM−1·s−1)
Carbapenems
Imipenem	2 [50] 4.8 [51] 22.48 [69] 6.7 ± 0.2 [30] 2.7 ± 0.2 [107] 4.5 ± 0.8 [108] 1.5 ± 0.1 [109] 1 [106] 4.8 ± 0.2 [79] 11.4 ± 0.5 [110] 5 ± 0.3 [111]	14 [50] 13 [51] 28.3 [69] 5.3 ± 0.6 [30] 3.7 ± 0.7 [107] 7.9 ± 0.1 [108] 60.3 ± 12.4 [109] 15 [106] 13 ± 2 [79] 57.7 ± 9.3 [110] 2.3 ± 0.07 [111]	145 [50] 370 [51] 794 [69] (1.3 ± 0.2)x103 [30] 900 [107] 570 [108] 25 [109] 70 [106] 365 ± 71 [79] 200 ± 30 [110] (2.0 ± 0.2)x103 [111]
Meropenem	0.1 [50] 0.07 [51] 0.112 [69] 0.16 ± 0.01 [30] 0.11 ± 0.01 [107] 0.098 ± 0.005 [108] 0.71 ± 0.02 [79] 0.087 ± 0.01 [110] 0.12 ± 0.001 [111]	200 [50] 11 [51] 5.5 [69] ≤2.0 [30] 6.0 ± 1.2 [107] 1.0 ± 0.2 [108] 4 ± 1 [79] <1.9 [110] 0.06 ± 0.002 [111]	0.5 [50] 6.2 [51] 20.4 [69] ≥80 [30] 17 [107] 98 [108] 177 ± 50 [79] <45 [110] (1.9 ± 0.1)x103 [111]
Ertapenem	0.13 [51] 0.112 [69] 0.067 ± 0.001 [30] 0.3 ± 0.02 [109] 0.03 ± 0.002 [111]	100 [51] 2.4 [69] ≤2.0 [30] 123.7 ± 36.2 [109] 0.2 ± 0.003 [111]	1.3 [51] 46.7 [69] ≥34 [30] 2 [109] 200 ± 30 [111]
Doripenem	ND [69] 0.14 ± 0.01 [30] 0.066 ± 0.002 [107]	≤2.0 [30] 4.1 ± 0.6 [107]	≥70 [30] 16 [107]
Panipenem	1.4 [51]	14 [51]	100 [51]
Faropenem	0.038 [51]	13 [51]	2.9 [51]
Penicillins
Benzylpenicillin (Penicillin G)	245 [50] 446 [112] (8.0 ± 1.1)x103 [108] 1750 [106]	40 [50] 79 [112] 700 ± 300 [108] 200 [106]	6.1x103 [50] 5.6x103 [112] 1.1x104 [108] 8.75x103 [106]
Oxacillin	25 [50] 130 [51] 160 ± 10 [30]	30 [50] 95 [51] ≤30 [30]	850 [50] 1.4x103 [51] ≥6x103 [30]
Ampicillin	340 [50] 955 [51] 1349 [69] 560 ± 30 [108] 370 [106] 608 ± 53 [79]	5200 [50] 395 [51] 572.7 [69] 150 ± 30 [108] 1.1x103 [106] 370 ± 70 [79]	65 [50] 2.4x103 [51] 2.36x103 [69] 3.7x103 [108] 340 [106] (1.64 ± 0.46)x103 [79]
Ticarcillin	45 [50] 70 [106]	55 [50] 90 [106]	820 [50] 780 [106]
Piperacillin	75 [50] 3.9 ± 0.5 [79]	410 [50] 898 ± 155 [79]	180 [50] 4 ± 1 [79]
Temocillin	0.3 [51]	45 [51]	6.6 [51]
Cephalosporins
Cephalothin	3 [50] 44 [51] 2.8 ± 0.1 [107]	20 [50] 195 [51] 140 ± 10 [107]	150 [50] 230 [51] 20 [107]
Cephaloridine	2 [50]	27 [50]	75 [50]
Cefoxitin	>0.05 [51]	>200 [51]	0.26 [51]
Cefotaxime	10 [50] >9 [51] ND [107] <0.001 [111]	190 [50] >900 [51] >1.0x103 [107] 174 ± 14 [111]	60 [50] 10 [51] 4.7 [107] <0.006 [111]
Ceftazidime	4 [50] ND [69] ND [107] 3.0 ± 0.8 [79] ND [111] ND [51]	5.1x103[50] ND [107] 300 ± 150 [79] (9.9 ± 0.74)x103 [111]	1 [50] ND [107] 10 ± 8 [79] ND [111]
Cefepime	1 [50] >0.6 [51] 7.87 [69] 9 ± 2 [108] 1.7 ± 0.6 [79]	160 [50] >550 [51] 2514.5 [69] 300 ± 110 [108] (1.68 ± 0.7)x103 [79]	6 [50] 1.1 [51] 3.13 [69] 30 [108] 1 ± 0.8 [79]
Cefpirome	8 [50]	390 [50]	20 [50]
Cefiderocol	<0.1 [106]	ND [106]	ND [106]
Monobactams
Aztreonam	ND [50]	ND [50]	ND [50]

ND: Hydrolysis not detected.