Table 1.

Examples of lncRNAs and their miRNA targets involved in myocardial and cerebral injuries.

Human Disease	LncRNA	miRNA target	Function	Examinated cell type	References
Myocardial Infarction	KLF3-AS1	miR-138-5p	Inhibit cardiomyocytes pyroptosis after MI	H9c2	[74]
	ANRIL	miR‐7‐5p	Protect H9c2 cells from hypoxia‐induced injury	H9c2	[75]
	ILF3-AS1	miR-212-3p	Relieve hypoxia damage, attenuate cardiomyocytes apoptosis	H9c2	[76]
	H19	miR-200a-3p	Increase CPCs proliferation and migration	CPCs	[77]
Myocardial Ischemia/Reperfusion	OIP5-AS1	miR-29a	Reduce reactive oxygen species, decreased cardiomyocytes apoptosis	H9c2	[80]
	ANRIL	miR‑181a	Inhibite lactate dehydrogenase release, prevent cardiomyocytes apoptosis	H9c2	[81]
	MALAT1	miR-217	Alleviate H9c2 cell injury	H9c2	[82]
Atherosclerosis	p21	miR-221	Increase HAECs proliferation and migration	HAECs	[85]
	Sirt1-AS	miR-22	Increase EPCs proliferation and migration	EPCs	[60]
	HAND2-AS1	miR-128	Alleviate the formation of foam cells in atherosclerosis	THP-1	[86]
Ischemic Stroke	SNHG8	miR‐425‐5p	Improve microglial inflammation	BMECs	[91]
		miR-449c-5p	Inhibit microglia activation, improve inflammation	Microglia	[92]
	SNHG7	miR-9	Enhance cell viability, reduce ROS and apoptosis	PC12	[93]
	MALAT1	miR-200c-3p	Stimulate cell survival, activate autophagy	BEMCs	[94]
	H19	miR-29b	Increase cell apoptosis and inflammatory cytokine	HT22	[95]
Cerebral Ischemia/Reperfusion	NEAT1	miR-377	Stimulate angiogenesis, inhibit apoptosis	BMECs	[98]
	SNHG12	miR-199a	Increased cell proliferation, suppress apoptosis	primary neuronal and N2a cells	[99]
	SNHG15	miR-141	Reduce oxidative stress markers	SH-SY5Y	[100]
	MALAT1	miR-142-3p	Stimulate cell proliferation, reduce oxidative stress, enhance antioxidant activities	PC12	[101]